2fda
From Proteopedia
(New page: 200px<br /> <applet load="2fda" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fda, resolution 2.00Å" /> '''Crystal Structure o...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2fda.gif|left|200px]]<br /> | + | [[Image:2fda.gif|left|200px]]<br /><applet load="2fda" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2fda" size=" | + | |
caption="2fda, resolution 2.00Å" /> | caption="2fda, resolution 2.00Å" /> | ||
'''Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand'''<br /> | '''Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort | + | Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents. |
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2FDA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with BCT, SO4 and 682 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http:// | + | 2FDA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BCT:'>BCT</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=682:'>682</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Coagulation_factor_XIa Coagulation factor XIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.27 3.4.21.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FDA OCA]. |
==Reference== | ==Reference== | ||
| Line 18: | Line 17: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Abdel-Meguid, S | + | [[Category: Abdel-Meguid, S S.]] |
| - | [[Category: Babine, R | + | [[Category: Babine, R E.]] |
[[Category: Jin, L.]] | [[Category: Jin, L.]] | ||
[[Category: Pandey, P.]] | [[Category: Pandey, P.]] | ||
| - | [[Category: Strickler, J | + | [[Category: Strickler, J E.]] |
| - | [[Category: Weaver, D | + | [[Category: Weaver, D T.]] |
[[Category: 682]] | [[Category: 682]] | ||
[[Category: BCT]] | [[Category: BCT]] | ||
| Line 30: | Line 29: | ||
[[Category: inhibitor]] | [[Category: inhibitor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:20:10 2008'' |
Revision as of 15:20, 21 February 2008
|
Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand
Contents |
Overview
Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents.
Disease
Known diseases associated with this structure: Factor XI deficiency, autosomal dominant OMIM:[264900], Factor XI deficiency, autosomal recessive OMIM:[264900]
About this Structure
2FDA is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Coagulation factor XIa, with EC number 3.4.21.27 Full crystallographic information is available from OCA.
Reference
Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine., Deng H, Bannister TD, Jin L, Babine RE, Quinn J, Nagafuji P, Celatka CA, Lin J, Lazarova TI, Rynkiewicz MJ, Bibbins F, Pandey P, Gorga J, Meyers HV, Abdel-Meguid SS, Strickler JE, Bioorg Med Chem Lett. 2006 Jun 1;16(11):3049-54. Epub 2006 Mar 9. PMID:16524727
Page seeded by OCA on Thu Feb 21 17:20:10 2008
Categories: Coagulation factor XIa | Homo sapiens | Single protein | Abdel-Meguid, S S. | Babine, R E. | Jin, L. | Pandey, P. | Strickler, J E. | Weaver, D T. | 682 | BCT | SO4 | Fxia | Inhibitor
