2bzg

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{{STRUCTURE_2bzg| PDB=2bzg | SCENE= }}
{{STRUCTURE_2bzg| PDB=2bzg | SCENE= }}
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'''CRYSTAL STRUCTURE OF THIOPURINE S-METHYLTRANSFERASE.'''
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===CRYSTAL STRUCTURE OF THIOPURINE S-METHYLTRANSFERASE.===
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==Overview==
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Human thiopurine S-methyltransferase (TPMT) exhibits considerable person-to-person variation in activity to thiopurine drugs. We have produced an N-terminal truncation of human TPMT protein, crystallized the protein in complex with the methyl donor product S-adenosyl-L-homocysteine, and determined the atomic structure to the resolution of 1.58 and 1.89 A, respectively, for the seleno-methionine incorporated and wild type proteins. The structure of TPMT indicates that the naturally occurring amino acid polymorphisms scatter throughout the structure, and that the amino acids whose alteration have the most influence on function are those that form intra-molecular stabilizing interactions (mainly van der Waals contacts). Furthermore, we have produced four TPMT mutant proteins containing variant alleles of TPMT*2, *3A, *3B, and *3C and examined the structure-function relationship of the mutant proteins based on their expression and solubility in bacteria and their thermostability profile.
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{{ABSTRACT_PUBMED_17243178}}
==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:00:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:10:15 2008''

Revision as of 08:10, 28 July 2008

Image:2bzg.png

Template:STRUCTURE 2bzg

CRYSTAL STRUCTURE OF THIOPURINE S-METHYLTRANSFERASE.

Template:ABSTRACT PUBMED 17243178

About this Structure

2BZG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of allele variation of human thiopurine-S-methyltransferase., Wu H, Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Cheng X, Proteins. 2007 Apr 1;67(1):198-208. PMID:17243178

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