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2c08

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{{STRUCTURE_2c08| PDB=2c08 | SCENE= }}
{{STRUCTURE_2c08| PDB=2c08 | SCENE= }}
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'''RAT ENDOPHILIN A1 BAR DOMAIN'''
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===RAT ENDOPHILIN A1 BAR DOMAIN===
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==Overview==
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Endophilin-A1 is a BAR domain-containing protein enriched at synapses and is implicated in synaptic vesicle endocytosis. It binds to dynamin and synaptojanin via a C-terminal SH3 domain. We examine the mechanism by which the BAR domain and an N-terminal amphipathic helix, which folds upon membrane binding, work as a functional unit (the N-BAR domain) to promote dimerisation and membrane curvature generation. By electron paramagnetic resonance spectroscopy, we show that this amphipathic helix is peripherally bound in the plane of the membrane, with the midpoint of insertion aligned with the phosphate level of headgroups. This places the helix in an optimal position to effect membrane curvature generation. We solved the crystal structure of rat endophilin-A1 BAR domain and examined a distinctive insert protruding from the membrane interaction face. This insert is predicted to form an additional amphipathic helix and is important for curvature generation. Its presence defines an endophilin/nadrin subclass of BAR domains. We propose that N-BAR domains function as low-affinity dimers regulating binding partner recruitment to areas of high membrane curvature.
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(as it appears on PubMed at http://www.pubmed.gov), where 16763559 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16763559}}
==About this Structure==
==About this Structure==
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[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:02:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:54:58 2008''

Revision as of 16:55, 28 July 2008

Image:2c08.png

Template:STRUCTURE 2c08

RAT ENDOPHILIN A1 BAR DOMAIN

Template:ABSTRACT PUBMED 16763559

About this Structure

2C08 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Mechanism of endophilin N-BAR domain-mediated membrane curvature., Gallop JL, Jao CC, Kent HM, Butler PJ, Evans PR, Langen R, McMahon HT, EMBO J. 2006 Jun 21;25(12):2898-910. Epub 2006 Jun 8. PMID:16763559

Page seeded by OCA on Mon Jul 28 19:54:58 2008

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