2c0j

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{{STRUCTURE_2c0j| PDB=2c0j | SCENE= }}
{{STRUCTURE_2c0j| PDB=2c0j | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE BET3-TRS33 HETERODIMER'''
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===CRYSTAL STRUCTURE OF THE BET3-TRS33 HETERODIMER===
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==Overview==
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Transport protein particle (TRAPP) comprises a family of two highly related multiprotein complexes, with seven common subunits, that serve to target different classes of transport vesicles to their appropriate compartments. Defining the architecture of the complexes will advance our understanding of the functional differences between these highly related molecular machines. Genetic analyses in yeast suggested a specific interaction between the TRAPP subunits Bet3p and Trs33p. A mammalian bet3-trs33 complex was crystallized, and the structure was solved to 2.2 angstroms resolution. Intriguingly, the overall fold of the bet3 and trs33 monomers was similar, although the proteins had little overall sequence identity. In vitro experiments using yeast TRAPP subunits indicated that Bet3p binding to Trs33p facilitates the interaction between Bet3p and another TRAPP subunit, Bet5p. Mutational analysis suggests that yeast Trs33p facilitates other Bet3p protein-protein interactions. Furthermore, we show that Trs33p can increase the Golgi-localized pool of a mutated Bet3 protein normally found in the cytosol. We propose that one of the roles of Trs33p is to facilitate the incorporation of the Bet3p subunit into assembling TRAPP complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 16262728 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16262728}}
==About this Structure==
==About this Structure==
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[[Category: Palmitate]]
[[Category: Palmitate]]
[[Category: Transport protein endoplasmic reticulum]]
[[Category: Transport protein endoplasmic reticulum]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:03:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:53:41 2008''

Revision as of 16:53, 27 July 2008

Image:2c0j.png

Template:STRUCTURE 2c0j

CRYSTAL STRUCTURE OF THE BET3-TRS33 HETERODIMER

Template:ABSTRACT PUBMED 16262728

About this Structure

2C0J is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p., Kim MS, Yi MJ, Lee KH, Wagner J, Munger C, Kim YG, Whiteway M, Cygler M, Oh BH, Sacher M, Traffic. 2005 Dec;6(12):1183-95. PMID:16262728

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