2fix
From Proteopedia
(New page: 200px<br /> <applet load="2fix" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fix, resolution 3.50Å" /> '''Structure of human ...) |
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| - | [[Image:2fix.gif|left|200px]]<br /> | + | [[Image:2fix.gif|left|200px]]<br /><applet load="2fix" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2fix" size=" | + | |
caption="2fix, resolution 3.50Å" /> | caption="2fix, resolution 3.50Å" /> | ||
'''Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitiors'''<br /> | '''Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitiors'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A series of novel benzoxazole benzenesulfonamides was synthesized as | + | A series of novel benzoxazole benzenesulfonamides was synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase-1). Extensive SAR studies led to a potent inhibitor, 53, with an IC(50) of 0.57microM. Compound 17 exhibited excellent bioavailability and a good pharmacokinetic profile in rats. |
==Disease== | ==Disease== | ||
| - | Known disease associated with this structure: Fructose- | + | Known disease associated with this structure: Fructose-1,6-bidphosphatase deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611570 611570]] |
==About this Structure== | ==About this Structure== | ||
| - | 2FIX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 870 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] Full crystallographic information is available from [http:// | + | 2FIX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=870:'>870</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIX OCA]. |
==Reference== | ==Reference== | ||
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[[Category: intersubunit allosteric inhibitors of human liver fbpase]] | [[Category: intersubunit allosteric inhibitors of human liver fbpase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:21:51 2008'' |
Revision as of 15:22, 21 February 2008
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Structure of human liver FBPase complexed with potent benzoxazole allosteric inhibitiors
Contents |
Overview
A series of novel benzoxazole benzenesulfonamides was synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase-1). Extensive SAR studies led to a potent inhibitor, 53, with an IC(50) of 0.57microM. Compound 17 exhibited excellent bioavailability and a good pharmacokinetic profile in rats.
Disease
Known disease associated with this structure: Fructose-1,6-bidphosphatase deficiency OMIM:[611570]
About this Structure
2FIX is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Fructose-bisphosphatase, with EC number 3.1.3.11 Full crystallographic information is available from OCA.
Reference
Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase., Lai C, Gum RJ, Daly M, Fry EH, Hutchins C, Abad-Zapatero C, von Geldern TW, Bioorg Med Chem Lett. 2006 Apr 1;16(7):1807-10. Epub 2006 Jan 30. PMID:16446092
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