2c2a

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{{STRUCTURE_2c2a| PDB=2c2a | SCENE= }}
{{STRUCTURE_2c2a| PDB=2c2a | SCENE= }}
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'''STRUCTURE OF THE ENTIRE CYTOPLASMIC PORTION OF A SENSOR HISTIDINE KINASE PROTEIN'''
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===STRUCTURE OF THE ENTIRE CYTOPLASMIC PORTION OF A SENSOR HISTIDINE KINASE PROTEIN===
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==Overview==
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The large majority of histidine kinases (HKs) are multifunctional enzymes having autokinase, phosphotransfer and phosphatase activities, and most of these are transmembrane sensor proteins. Sensor HKs possess conserved cytoplasmic phosphorylation and ATP-binding kinase domains. The different enzymatic activities require participation by one or both of these domains, implying the need for different conformational states. The catalytic domains are linked to the membrane through a coiled-coil segment that sometimes includes other domains. We describe here the first crystal structure of the complete cytoplasmic region of a sensor HK, one from the thermophile Thermotoga maritima in complex with ADPbetaN at 1.9 A resolution. The structure reveals previously unidentified functions for several conserved residues and reveals the relative disposition of domains in a state seemingly poised for phosphotransfer. The structure thereby inspires hypotheses for the mechanisms of autophosphorylation, phosphotransfer and response-regulator dephosphorylation, and for signal transduction through the coiled-coil segment. Mutational tests support the functional relevance of interdomain contacts.
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The line below this paragraph, {{ABSTRACT_PUBMED_16319927}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16319927 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16319927}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Two-component system]]
[[Category: Two-component system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:08:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:21:11 2008''

Revision as of 13:21, 28 July 2008

Image:2c2a.png

Template:STRUCTURE 2c2a

STRUCTURE OF THE ENTIRE CYTOPLASMIC PORTION OF A SENSOR HISTIDINE KINASE PROTEIN

Template:ABSTRACT PUBMED 16319927

About this Structure

2C2A is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein., Marina A, Waldburger CD, Hendrickson WA, EMBO J. 2005 Dec 21;24(24):4247-59. Epub 2005 Dec 1. PMID:16319927

Page seeded by OCA on Mon Jul 28 16:21:11 2008

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