2c4d

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{{STRUCTURE_2c4d| PDB=2c4d | SCENE= }}
{{STRUCTURE_2c4d| PDB=2c4d | SCENE= }}
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'''2.6A CRYSTAL STRUCTURE OF PSATHYRELLA VELUTINA LECTIN IN COMPLEX WITH N-ACETYLGLUCOSAMINE'''
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===2.6A CRYSTAL STRUCTURE OF PSATHYRELLA VELUTINA LECTIN IN COMPLEX WITH N-ACETYLGLUCOSAMINE===
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==Overview==
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The lectin from the mushroom Psathyrella velutina recognises specifically N-acetylglucosamine and N-acetylneuraminic acid containing glycans. The crystal structure of the 401 amino acid residue lectin shows that it adopts a very regular seven-bladed beta-propeller fold with the N-terminal region tucked into the central cavity around the pseudo 7-fold axis. In the complex with N-acetylglucosamine, six monosaccharides are bound in pockets located between two consecutive propeller blades. Due to the repeats shown by the sequence the binding sites are very similar. Five hydrogen bonds between the protein and the sugar hydroxyl and N-acetyl groups stabilize the complex, together with the hydrophobic interactions with a conserved tyrosine and histidine. The complex with N-acetylneuraminic acid shows molecular mimicry with the same hydrogen bond network, but with different orientations of the carbohydrate ring in the binding site. The beta-hairpin loops connecting the two inner beta-strands of each blade are metal binding sites and two to three calcium ions were located in the structure. The multispecificity and high multivalency of this mushroom lectin, combined with its similarity to the extracellular domain of an important class of cell adhesion molecules, integrins, are another example of the outstanding success of beta-propeller structures as molecular binding machines in nature.
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{{ABSTRACT_PUBMED_16497330}}
==About this Structure==
==About this Structure==
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[[Category: N-acetylglucosamine]]
[[Category: N-acetylglucosamine]]
[[Category: Psathyrella velutina]]
[[Category: Psathyrella velutina]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:54:10 2008''

Revision as of 20:54, 28 July 2008

Image:2c4d.png

Template:STRUCTURE 2c4d

2.6A CRYSTAL STRUCTURE OF PSATHYRELLA VELUTINA LECTIN IN COMPLEX WITH N-ACETYLGLUCOSAMINE

Template:ABSTRACT PUBMED 16497330

About this Structure

2C4D is a Single protein structure of sequence from Lacrymaria velutina. Full crystallographic information is available from OCA.

Reference

Beta-propeller crystal structure of Psathyrella velutina lectin: an integrin-like fungal protein interacting with monosaccharides and calcium., Cioci G, Mitchell EP, Chazalet V, Debray H, Oscarson S, Lahmann M, Gautier C, Breton C, Perez S, Imberty A, J Mol Biol. 2006 Apr 14;357(5):1575-91. Epub 2006 Feb 6. PMID:16497330

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