2c55

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{{STRUCTURE_2c55| PDB=2c55 | SCENE= }}
{{STRUCTURE_2c55| PDB=2c55 | SCENE= }}
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'''SOLUTION STRUCTURE OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 P6 PROTEIN'''
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===SOLUTION STRUCTURE OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 P6 PROTEIN===
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==Overview==
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The human immunodeficiency virus type 1 p6 protein represents a docking site for several cellular and viral binding factors and fulfills major roles in the formation of infectious viruses. To date, however, the structure of this 52-amino acid protein, by far the smallest lentiviral protein known, either in its mature form as free p6 or as the C-terminal part of the Pr55 Gag polyprotein has not been unraveled. We have explored the high resolution structure and folding of p6 by CD and NMR spectroscopy. Under membranous solution conditions, p6 can adopt a helix-flexible helix structure; a short helix-1 (amino acids 14-18) is connected to a pronounced helix-2 (amino acids 33-44) by a flexible hinge region. Thus, p6 can be subdivided into two distinct structural and functional domains; helix-2 perfectly defines the region that binds to the virus budding factor AIP-1/ALIX, indicating that this structure is required for interaction with the endosomal sorting complex required for transport. The PTAP motif at the N terminus, comprising the primary late assembly domain, which is crucial for interaction with another cellular budding factor, Tsg101, does not exhibit secondary structure. However, the adjacent helix-1 may play an indirect role in the specific complex formation between p6 and the binding groove in Tsg101. Moreover, binding studies by NMR demonstrate that helix-2, which also comprises the LXXLF motif required for incorporation of the human immunodeficiency virus type 1 accessory protein Vpr into budding virions, specifically interacts with the Vpr binding region, indicating that under the specific solution conditions used for structure analysis, p6 adopted a functional conformation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16234236 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16234236}}
==About this Structure==
==About this Structure==
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2C55 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C55 OCA].
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2C55 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C55 OCA].
==Reference==
==Reference==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:15:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:01:07 2008''

Revision as of 13:01, 28 July 2008

Image:2c55.png

Template:STRUCTURE 2c55

SOLUTION STRUCTURE OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 P6 PROTEIN

Template:ABSTRACT PUBMED 16234236

About this Structure

2C55 is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of the human immunodeficiency virus type 1 p6 protein., Fossen T, Wray V, Bruns K, Rachmat J, Henklein P, Tessmer U, Maczurek A, Klinger P, Schubert U, J Biol Chem. 2005 Dec 30;280(52):42515-27. Epub 2005 Oct 17. PMID:16234236

Page seeded by OCA on Mon Jul 28 16:01:07 2008

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