2c57

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{{STRUCTURE_2c57| PDB=2c57 | SCENE= }}
{{STRUCTURE_2c57| PDB=2c57 | SCENE= }}
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'''H.PYLORI TYPE II DEHYDROQUINASE IN COMPLEX WITH FA1'''
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===H.PYLORI TYPE II DEHYDROQUINASE IN COMPLEX WITH FA1===
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==Overview==
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The crystal structures of the type II dehydroquinase (DHQase) from Helicobacter pylori in complex with three competitive inhibitors have been determined. The inhibitors are the substrate analogue 2,3-anhydroquinate (FA1), citrate, and an oxoxanthene sulfonamide derivative (AH9095). Despite the very different chemical nature of the inhibitors, in each case the primary point of interaction with the enzyme is via the residues that bind the C1 functionalities of the substrate, 3-dehydroquinate, i.e., N76, H102, I103, and H104. The DHQase/AH9095 complex crystal structure shows that sulfonamides can form a scaffold for nonsubstrate-like inhibitors and identifies a large conserved hydrophobic patch at the entrance to the active site as a locus that can be exploited in the development of new ligands.
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{{ABSTRACT_PUBMED_16480265}}
==About this Structure==
==About this Structure==
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[[Category: Shikimate pathway]]
[[Category: Shikimate pathway]]
[[Category: Sulphonamide]]
[[Category: Sulphonamide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:31:37 2008''

Revision as of 12:31, 27 July 2008

Image:2c57.png

Template:STRUCTURE 2c57

H.PYLORI TYPE II DEHYDROQUINASE IN COMPLEX WITH FA1

Template:ABSTRACT PUBMED 16480265

About this Structure

2C57 is a Single protein structure of sequence from Helicobacter pylori. Full crystallographic information is available from OCA.

Reference

Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design., Robinson DA, Stewart KA, Price NC, Chalk PA, Coggins JR, Lapthorn AJ, J Med Chem. 2006 Feb 23;49(4):1282-90. PMID:16480265

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