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2c62

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{{STRUCTURE_2c62| PDB=2c62 | SCENE= }}
{{STRUCTURE_2c62| PDB=2c62 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA'''
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===CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA===
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==Overview==
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The 1.74-A crystal structure of the human transcription cofactor PC4 in complex with a single-stranded 20-mer oligonucleotide reveals how symmetry-related beta-surfaces of the protein homodimer interact with juxtaposed 5-nucleotide DNA regions running in opposite directions. The structure explains high-affinity binding of PC4 to the complementary strands of unwinding duplex DNA, and it suggests the cofactor may have a role in relaxing negative supercoils or exposing unpaired bases for sequence-specific recognition by other biomolecules.
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(as it appears on PubMed at http://www.pubmed.gov), where 16415882 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16415882}}
==About this Structure==
==About this Structure==
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[[Category: Transcription cofactor]]
[[Category: Transcription cofactor]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:18:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:15:40 2008''

Revision as of 11:15, 28 July 2008

Image:2c62.png

Template:STRUCTURE 2c62

CRYSTAL STRUCTURE OF THE HUMAN TRANSCRIPTION COFACTOR PC4 IN COMPLEX WITH SINGLE-STRANDED DNA

Template:ABSTRACT PUBMED 16415882

About this Structure

2C62 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A global transcription cofactor bound to juxtaposed strands of unwound DNA., Werten S, Moras D, Nat Struct Mol Biol. 2006 Feb;13(2):181-2. Epub 2006 Jan 15. PMID:16415882

Page seeded by OCA on Mon Jul 28 14:15:40 2008

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