2c74

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{{STRUCTURE_2c74| PDB=2c74 | SCENE= }}
{{STRUCTURE_2c74| PDB=2c74 | SCENE= }}
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'''14-3-3 PROTEIN ETA (HUMAN) COMPLEXED TO PEPTIDE'''
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===14-3-3 PROTEIN ETA (HUMAN) COMPLEXED TO PEPTIDE===
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==Overview==
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The seven members of the human 14-3-3 protein family regulate a diverse range of cell signaling pathways by formation of protein-protein complexes with signaling proteins that contain phosphorylated Ser/Thr residues within specific sequence motifs. Previously, crystal structures of three 14-3-3 isoforms (zeta, sigma, and tau) have been reported, with structural data for two isoforms deposited in the Protein Data Bank (zeta and sigma). In this study, we provide structural detail for five 14-3-3 isoforms bound to ligands, providing structural coverage for all isoforms of a human protein family. A comparative structural analysis of the seven 14-3-3 proteins revealed specificity determinants for binding of phosphopeptides in a specific orientation, target domain interaction surfaces and flexible adaptation of 14-3-3 proteins through domain movements. Specifically, the structures of the beta isoform in its apo and peptide bound forms showed that its binding site can exhibit structural flexibility to facilitate binding of its protein and peptide partners. In addition, the complex of 14-3-3 beta with the exoenzyme S peptide displayed a secondary structural element in the 14-3-3 peptide binding groove. These results show that the 14-3-3 proteins are adaptable structures in which internal flexibility is likely to facilitate recognition and binding of their interaction partners.
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{{ABSTRACT_PUBMED_17085597}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Phosphoserine]]
[[Category: Phosphoserine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:21:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:40:59 2008''

Revision as of 02:41, 28 July 2008

Image:2c74.png

Template:STRUCTURE 2c74

14-3-3 PROTEIN ETA (HUMAN) COMPLEXED TO PEPTIDE

Template:ABSTRACT PUBMED 17085597

About this Structure

2C74 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for protein-protein interactions in the 14-3-3 protein family., Yang X, Lee WH, Sobott F, Papagrigoriou E, Robinson CV, Grossmann JG, Sundstrom M, Doyle DA, Elkins JM, Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17237-42. Epub 2006 Nov 3. PMID:17085597

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