2c7c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2c7c.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2c7c.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2c7c| PDB=2c7c | SCENE= }}
{{STRUCTURE_2c7c| PDB=2c7c | SCENE= }}
-
'''FITTED COORDINATES FOR GROEL-ATP7-GROES CRYO-EM COMPLEX (EMD-1180)'''
+
===FITTED COORDINATES FOR GROEL-ATP7-GROES CRYO-EM COMPLEX (EMD-1180)===
-
==Overview==
+
<!--
-
The double-ring chaperonin GroEL and its lid-like cochaperonin GroES form asymmetric complexes that, in the ATP-bound state, mediate productive folding in a hydrophilic, GroES-encapsulated chamber, the so-called cis cavity. Upon ATP hydrolysis within the cis ring, the asymmetric complex becomes able to accept non-native polypeptides and ATP in the open, trans ring. Here we have examined the structural basis for this allosteric switch in activity by cryo-EM and single-particle image processing. ATP hydrolysis does not change the conformation of the cis ring, but its effects are transmitted through an inter-ring contact and cause domain rotations in the mobile trans ring. These rigid-body movements in the trans ring lead to disruption of its intra-ring contacts, expansion of the entire ring and opening of both the nucleotide pocket and the substrate-binding domains, admitting ATP and new substrate protein.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16429154}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16429154 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16429154}}
==About this Structure==
==About this Structure==
Line 36: Line 40:
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:22:32 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:07:19 2008''

Revision as of 16:07, 27 July 2008

Image:2c7c.png

Template:STRUCTURE 2c7c

FITTED COORDINATES FOR GROEL-ATP7-GROES CRYO-EM COMPLEX (EMD-1180)

Template:ABSTRACT PUBMED 16429154

About this Structure

2C7C is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes., Ranson NA, Clare DK, Farr GW, Houldershaw D, Horwich AL, Saibil HR, Nat Struct Mol Biol. 2006 Feb;13(2):147-52. Epub 2006 Jan 22. PMID:16429154

Page seeded by OCA on Sun Jul 27 19:07:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c7c"
Personal tools