2c8t

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{{STRUCTURE_2c8t| PDB=2c8t | SCENE= }}
{{STRUCTURE_2c8t| PDB=2c8t | SCENE= }}
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'''THE 3.0 A RESOLUTION STRUCTURE OF CASEINOLYTIC CLP PROTEASE 1 FROM MYCOBACTERIUM TUBERCULOSIS'''
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===THE 3.0 A RESOLUTION STRUCTURE OF CASEINOLYTIC CLP PROTEASE 1 FROM MYCOBACTERIUM TUBERCULOSIS===
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==Overview==
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Mycobacterium tuberculosis caseinolytic protease ClpP1 (Mt ClpP1) is a self-compartmentalized protease consisting of two heptameric rings stacked on top of each other, thus enclosing a catalytic chamber. Within the chamber, which can be reached through two axial pores, each of the 14 identical monomers possesses a serine protease active site. The unfolding and translocation of substrates into the chamber are mediated by associated hexameric ATPases covering the axial pores. Three crystal structures of Mt ClpP1, determined by molecular replacement, are presented in this study. Two of the models were refined to a resolution of 2.6 A and the third to 3.0 A. It was found that disorder in the handle domain affects the formation and configuration of the tetradecamer and results in condensed structures with larger equatorial pores when compared with ClpPs from other species. Additionally, this disorder accompanies conformational changes of the residues in the catalytic triad. The models also reveal structural differences within the N-terminal hairpin-loop domain, which possibly reflect the significant differences in amino-acid sequence between Mt ClpP1 and other ClpP homologues in this region.
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(as it appears on PubMed at http://www.pubmed.gov), where 17242518 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17242518}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Tetradecamer]]
[[Category: Tetradecamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:27:45 2008''
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Revision as of 18:05, 27 July 2008

Image:2c8t.png

Template:STRUCTURE 2c8t

THE 3.0 A RESOLUTION STRUCTURE OF CASEINOLYTIC CLP PROTEASE 1 FROM MYCOBACTERIUM TUBERCULOSIS

Template:ABSTRACT PUBMED 17242518

About this Structure

2C8T is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1., Ingvarsson H, Mate MJ, Hogbom M, Portnoi D, Benaroudj N, Alzari PM, Ortiz-Lombardia M, Unge T, Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):249-59. Epub 2007, Jan 16. PMID:17242518

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