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2cgt

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[[Image:2cgt.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2cgt| PDB=2cgt | SCENE= }}
{{STRUCTURE_2cgt| PDB=2cgt | SCENE= }}
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'''GROEL-ADP-GP31 COMPLEX'''
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===GROEL-ADP-GP31 COMPLEX===
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==Overview==
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Bacteriophage T4 produces a GroES analogue, gp31, which cooperates with the Escherichia coli GroEL to fold its major coat protein gp23. We have used cryo-electron microscopy and image processing to obtain three-dimensional structures of the E.coli chaperonin GroEL complexed with gp31, in the presence of both ATP and ADP. The GroEL-gp31-ADP map has a resolution of 8.2 A, which allows accurate fitting of the GroEL and gp31 crystal structures. Comparison of this fitted structure with that of the GroEL-GroES-ADP structure previously determined by cryo-electron microscopy shows that the folding cage is expanded. The enlarged volume for folding is consistent with the size of the bacteriophage coat protein gp23, which is the major substrate of GroEL-gp31 chaperonin complex. At 56 kDa, gp23 is close to the maximum size limit of a polypeptide that is thought to fit inside the GroEL-GroES folding cage.
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(as it appears on PubMed at http://www.pubmed.gov), where 16549073 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16549073}}
==About this Structure==
==About this Structure==
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[[Category: Gp31]]
[[Category: Gp31]]
[[Category: Groel]]
[[Category: Groel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:06:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:40:51 2008''

Revision as of 12:40, 28 July 2008

Image:2cgt.png

Template:STRUCTURE 2cgt

GROEL-ADP-GP31 COMPLEX

Template:ABSTRACT PUBMED 16549073

About this Structure

2CGT is a Protein complex structure of sequences from Enterobacteria phage t4 and Escherichia coli. Full crystallographic information is available from OCA.

Reference

An expanded protein folding cage in the GroEL-gp31 complex., Clare DK, Bakkes PJ, van Heerikhuizen H, van der Vies SM, Saibil HR, J Mol Biol. 2006 May 5;358(3):905-11. Epub 2006 Mar 6. PMID:16549073

Page seeded by OCA on Mon Jul 28 15:40:51 2008

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