2chd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2chd.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2chd.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2chd| PDB=2chd | SCENE= }}
{{STRUCTURE_2chd| PDB=2chd | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE C2A DOMAIN OF RABPHILIN-3A'''
+
===CRYSTAL STRUCTURE OF THE C2A DOMAIN OF RABPHILIN-3A===
-
==Overview==
+
<!--
-
Rabphilin-3A is a neuronal protein containing a C2-domain tandem. To date, only the structure of the C2B domain has been solved. The crystal structure of the Ca2+-free C2A domain has been solved by molecular replacement and refined to 1.92 A resolution. It adopts the classical C2-domain fold consisting of an eight-stranded antiparallel beta-sandwich with type I topology. In agreement with its Ca2+-dependent negatively charged membrane-binding properties, this C2 domain contains all the conserved acidic residues responsible for calcium binding. However, the replacement of a conserved aspartic acid residue by glutamic acid allows formation of an additional strong hydrogen bond, resulting in increased rigidity of calcium-binding loop 1. The electrostatic surface of the C2A domain consists of a large positively charged belt surrounded by two negatively charged patches located at both tips of the domain. In comparison, the structurally very similar C2A domain of synaptotagmin I has a highly acidic electrostatic surface, suggesting completely unrelated functions for these two C2A domains.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16790935}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16790935 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16790935}}
==About this Structure==
==About this Structure==
Line 37: Line 41:
[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:08:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:20:28 2008''

Revision as of 14:20, 28 July 2008

Image:2chd.png

Template:STRUCTURE 2chd

CRYSTAL STRUCTURE OF THE C2A DOMAIN OF RABPHILIN-3A

Template:ABSTRACT PUBMED 16790935

About this Structure

2CHD is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the C2A domain of rabphilin-3A., Biadene M, Montaville P, Sheldrick GM, Becker S, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):793-9. Epub 2006, Jun 20. PMID:16790935

Page seeded by OCA on Mon Jul 28 17:20:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2chd"
Personal tools