2chj

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[[Image:2chj.gif|left|200px]]
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{{STRUCTURE_2chj| PDB=2chj | SCENE= }}
{{STRUCTURE_2chj| PDB=2chj | SCENE= }}
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'''NMR STRUCTURE OF TGLGLT QUADRUPLEX'''
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===NMR STRUCTURE OF TGLGLT QUADRUPLEX===
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==Overview==
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We have determined the NMR solution structures of the quadruplexes formed by d(TGLGLT) and d(TL4T), where L denotes LNA (locked nucleic acid) modified G-residues. Both structures are tetrameric, parallel and right-handed and the native global fold of the corresponding DNA quadruplex is retained upon introduction of the LNA nucleotides. However, local structural alterations are observed owing to the locked LNA sugars. In particular, a distinct change in the sugar-phosphate backbone is observed at the G2pL3 and L2pL3 base steps and sequence dependent changes in the twist between tetrads are also seen. Both the LNA modified quadruplexes have raised thermostability as compared to the DNA quadruplex. The quadruplex-forming capability of d(TGLGLT) is of particular interest as it expands the design flexibility for stable parallel LNA quadruplexes and shows that LNA nucleotides can be mixed with DNA or other modified nucleic acids. As such, LNA-based quadruplexes can be decorated by a variety of chemical modifications. Such LNA quadruplex scaffolds might find applications in the developing field of nanobiotechnology.
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(as it appears on PubMed at http://www.pubmed.gov), where 16614450 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16614450}}
==About this Structure==
==About this Structure==
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2CHJ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHJ OCA].
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2CHJ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHJ OCA].
==Reference==
==Reference==
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[[Category: Locked nucleic acid]]
[[Category: Locked nucleic acid]]
[[Category: Quadruplex]]
[[Category: Quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:09:20 2008''
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Revision as of 09:27, 27 July 2008

Image:2chj.png

Template:STRUCTURE 2chj

NMR STRUCTURE OF TGLGLT QUADRUPLEX

Template:ABSTRACT PUBMED 16614450

About this Structure

2CHJ is a Single protein structure. Full experimental information is available from OCA.

Reference

NMR solution structures of LNA (locked nucleic acid) modified quadruplexes., Nielsen JT, Arar K, Petersen M, Nucleic Acids Res. 2006 Apr 13;34(7):2006-14. Print 2006. PMID:16614450

Page seeded by OCA on Sun Jul 27 12:27:14 2008

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