2ckb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ckb.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ckb.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ckb| PDB=2ckb | SCENE= }}
{{STRUCTURE_2ckb| PDB=2ckb | SCENE= }}
-
'''STRUCTURE OF THE 2C/KB/DEV8 COMPLEX'''
+
===STRUCTURE OF THE 2C/KB/DEV8 COMPLEX===
-
==Overview==
+
<!--
-
The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens in the thymus during maturation and then discriminate between foreign pathogens in the periphery. A molecular basis for this cross-reactivity is elucidated by the crystal structure of the alloreactive 2C TCR bound to self peptide-major histocompatibility complex (pMHC) antigen H-2Kb-dEV8 refined against anisotropic 3.0 angstrom resolution x-ray data. The interface between peptide and TCR exhibits extremely poor shape complementarity, and the TCR beta chain complementarity-determining region 3 (CDR3) has minimal interaction with the dEV8 peptide. Large conformational changes in three of the TCR CDR loops are induced upon binding, providing a mechanism of structural plasticity to accommodate a variety of different peptide antigens. Extensive TCR interaction with the pMHC alpha helices suggests a generalized orientation that is mediated by the Valpha domain of the TCR and rationalizes how TCRs can effectively "scan" different peptides bound within a large, low-affinity MHC structural framework for those that provide the slight additional kinetic stabilization required for signaling.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9469799}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9469799 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9469799}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Major histocompatibility complex]]
[[Category: Major histocompatibility complex]]
[[Category: T cell antigen receptor]]
[[Category: T cell antigen receptor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:20:57 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:56:10 2008''

Revision as of 10:56, 27 July 2008

Image:2ckb.png

Template:STRUCTURE 2ckb

STRUCTURE OF THE 2C/KB/DEV8 COMPLEX

Template:ABSTRACT PUBMED 9469799

About this Structure

2CKB is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen., Garcia KC, Degano M, Pease LR, Huang M, Peterson PA, Teyton L, Wilson IA, Science. 1998 Feb 20;279(5354):1166-72. PMID:9469799

Page seeded by OCA on Sun Jul 27 13:56:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ckb"
Personal tools