2cps

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2cps.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2cps.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2cps| PDB=2cps | SCENE= }}
{{STRUCTURE_2cps| PDB=2cps | SCENE= }}
-
'''SOLUTION NMR STRUCTURES OF THE MAJOR COAT PROTEIN OF FILAMENTOUS BACTERIOPHAGE M13 SOLUBILIZED IN SODIUM DODECYL SULPHATE MICELLES, 25 LOWEST ENERGY STRUCTURES'''
+
===SOLUTION NMR STRUCTURES OF THE MAJOR COAT PROTEIN OF FILAMENTOUS BACTERIOPHAGE M13 SOLUBILIZED IN SODIUM DODECYL SULPHATE MICELLES, 25 LOWEST ENERGY STRUCTURES===
-
==Overview==
+
<!--
-
The three-dimensional structure of the major coat protein of bacteriophage M13, solubilized in detergent micelles, has been determined using heteronuclear multidimensional NMR and restrained molecular dynamics. The protein consists of two alpha-helices, running from residues 8 to 16 and 25 to 45, respectively. These two helices are connected by a flexible and distorted helical hinge region. The structural properties of the coat protein make it resemble a flail, in which the hydrophobic helix (residues 25 to 45) is the handle and the other, amphipathic, helix the swingle. In this metaphor, the hinge region is the connecting piece of leather. The mobility of the residues in the hinge region is likely to enable a smooth transformation from the membrane-bound form, mimicked by the structure in detergent micelles, into the structure in the mature phage. A specific distribution of the residues over the surface of the two helices was observed in the presented high-resolution structure of the membrane-bound form of the major coat protein as well as in the structure in the mature phage. All data suggest that this arrangement of residues is important for the interactions of the protein with the membrane, for correct protein-DNA and protein-protein interactions in the phage and for a proper growth of the phage during the assembly process. By combining our findings with earlier NMR results on the major coat protein in detergent micelles, we were able to construct a model that addresses the role of specific residues in the assembly process.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9735296}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9735296 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9735296}}
==About this Structure==
==About this Structure==
-
2CPS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_m13 Enterobacteria phage m13]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPS OCA].
+
2CPS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_m13 Enterobacteria phage m13]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CPS OCA].
==Reference==
==Reference==
Line 32: Line 36:
[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Micelle]]
[[Category: Micelle]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:45:30 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:17:35 2008''

Revision as of 04:17, 29 July 2008

Image:2cps.png

Template:STRUCTURE 2cps

SOLUTION NMR STRUCTURES OF THE MAJOR COAT PROTEIN OF FILAMENTOUS BACTERIOPHAGE M13 SOLUBILIZED IN SODIUM DODECYL SULPHATE MICELLES, 25 LOWEST ENERGY STRUCTURES

Template:ABSTRACT PUBMED 9735296

About this Structure

2CPS is a Single protein structure of sequence from Enterobacteria phage m13. Full experimental information is available from OCA.

Reference

Solution structure of the M13 major coat protein in detergent micelles: a basis for a model of phage assembly involving specific residues., Papavoine CH, Christiaans BE, Folmer RH, Konings RN, Hilbers CW, J Mol Biol. 1998 Sep 18;282(2):401-19. PMID:9735296

Page seeded by OCA on Tue Jul 29 07:17:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2cps"
Personal tools