2gdo
From Proteopedia
(New page: 200px<br /> <applet load="2gdo" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gdo, resolution 3.00Å" /> '''4-(Aminoalkylamino)...) |
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| - | [[Image:2gdo. | + | [[Image:2gdo.jpg|left|200px]]<br /><applet load="2gdo" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2gdo, resolution 3.00Å" /> | caption="2gdo, resolution 3.00Å" /> | ||
'''4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors'''<br /> | '''4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2GDO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and 12C as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http:// | + | 2GDO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=12C:'>12C</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:03:06 2008'' |
Revision as of 13:03, 23 January 2008
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4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors
Overview
CHK-1 is one of the key enzymes regulating checkpoints in cellular growth, cycles. Novel 4-(amino-alkylamino)-3-benzimidazole-quinolinones were, prepared and assayed for their ability to inhibit CHK-1. These compounds, are potent cell permeable CHK-1 inhibitors and showed synergistic effect, with a DNA-damaging agent, camptothecin.
About this Structure
2GDO is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.
Reference
4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors., Ni ZJ, Barsanti P, Brammeier N, Diebes A, Poon DJ, Ng S, Pecchi S, Pfister K, Renhowe PA, Ramurthy S, Wagman AS, Bussiere DE, Le V, Zhou Y, Jansen JM, Ma S, Gesner TG, Bioorg Med Chem Lett. 2006 Jun 15;16(12):3121-4. Epub 2006 Apr 5. PMID:16603354
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