2cu7

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{{STRUCTURE_2cu7| PDB=2cu7 | SCENE= }}
{{STRUCTURE_2cu7| PDB=2cu7 | SCENE= }}
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'''Solution structure of the SANT domain of human KIAA1915 protein'''
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===Solution structure of the SANT domain of human KIAA1915 protein===
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==Overview==
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SWIRM is a conserved domain found in several chromatin-associated proteins. Based on their sequences, the SWIRM family members can be classified into three subfamilies, which are represented by Swi3, LSD1, and Ada2. Here we report the SWIRM structure of human MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM1). The MYSM1 SWIRM structure forms a compact HTH-related fold comprising five alpha-helices, which best resembles the Swi3 SWIRM structure, among the known SWIRM structures. The MYSM1 and Swi3 SWIRM structures are more similar to the LSD1 structure than the Ada2alpha structure. The SWIRM domains of MYSM1 and LSD1 lacked DNA binding activity, while those of Ada2alpha and the human Swi3 counterpart, SMARCC2, bound DNA. The dissimilarity in the DNA-binding ability of the MYSM1 and SMARCC2 SWIRM domains might be due to a couple of amino acid differences in the last helix. These results indicate that the SWIRM family has indeed diverged into three structural subfamilies (Swi3/MYSM1, LSD1, and Ada2 types), and that the Swi3/MYSM1-type subfamily has further diverged into two functionally distinct groups. We also solved the structure of the SANT domain of MYSM1, and demonstrated that it bound DNA with a similar mode to that of the c-Myb DNA-binding domain.
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{{ABSTRACT_PUBMED_17428495}}
==About this Structure==
==About this Structure==
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2CU7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CU7 OCA].
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2CU7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CU7 OCA].
==Reference==
==Reference==
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[[Category: Sant domain]]
[[Category: Sant domain]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:04:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:50:38 2008''

Revision as of 19:50, 27 July 2008

Image:2cu7.png

Template:STRUCTURE 2cu7

Solution structure of the SANT domain of human KIAA1915 protein

Template:ABSTRACT PUBMED 17428495

About this Structure

2CU7 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural and functional differences of SWIRM domain subtypes., Yoneyama M, Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Watanabe S, Tomo Y, Nishimura Y, Harada T, Terada T, Shirouzu M, Hayashizaki Y, Ohara O, Tanaka A, Kigawa T, Yokoyama S, J Mol Biol. 2007 May 25;369(1):222-38. Epub 2007 Mar 19. PMID:17428495

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