2cuj

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[[Image:2cuj.gif|left|200px]]
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{{STRUCTURE_2cuj| PDB=2cuj | SCENE= }}
{{STRUCTURE_2cuj| PDB=2cuj | SCENE= }}
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'''Solution structure of SWIRM domain of mouse transcriptional adaptor 2-like'''
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===Solution structure of SWIRM domain of mouse transcriptional adaptor 2-like===
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==Overview==
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SWIRM is a conserved domain found in several chromatin-associated proteins. Based on their sequences, the SWIRM family members can be classified into three subfamilies, which are represented by Swi3, LSD1, and Ada2. Here we report the SWIRM structure of human MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM1). The MYSM1 SWIRM structure forms a compact HTH-related fold comprising five alpha-helices, which best resembles the Swi3 SWIRM structure, among the known SWIRM structures. The MYSM1 and Swi3 SWIRM structures are more similar to the LSD1 structure than the Ada2alpha structure. The SWIRM domains of MYSM1 and LSD1 lacked DNA binding activity, while those of Ada2alpha and the human Swi3 counterpart, SMARCC2, bound DNA. The dissimilarity in the DNA-binding ability of the MYSM1 and SMARCC2 SWIRM domains might be due to a couple of amino acid differences in the last helix. These results indicate that the SWIRM family has indeed diverged into three structural subfamilies (Swi3/MYSM1, LSD1, and Ada2 types), and that the Swi3/MYSM1-type subfamily has further diverged into two functionally distinct groups. We also solved the structure of the SANT domain of MYSM1, and demonstrated that it bound DNA with a similar mode to that of the c-Myb DNA-binding domain.
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{{ABSTRACT_PUBMED_17428495}}
==About this Structure==
==About this Structure==
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2CUJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUJ OCA].
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2CUJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUJ OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Transcriptional regulation]]
[[Category: Transcriptional regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:06:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:53:26 2008''

Revision as of 05:53, 28 July 2008

Image:2cuj.png

Template:STRUCTURE 2cuj

Solution structure of SWIRM domain of mouse transcriptional adaptor 2-like

Template:ABSTRACT PUBMED 17428495

About this Structure

2CUJ is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structural and functional differences of SWIRM domain subtypes., Yoneyama M, Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Matsuda T, Watanabe S, Tomo Y, Nishimura Y, Harada T, Terada T, Shirouzu M, Hayashizaki Y, Ohara O, Tanaka A, Kigawa T, Yokoyama S, J Mol Biol. 2007 May 25;369(1):222-38. Epub 2007 Mar 19. PMID:17428495

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