2cxa

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{{STRUCTURE_2cxa| PDB=2cxa | SCENE= }}
{{STRUCTURE_2cxa| PDB=2cxa | SCENE= }}
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'''Crystal structure of Leucyl/phenylalanyl-tRNA protein transferase from Escherichia coli'''
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===Crystal structure of Leucyl/phenylalanyl-tRNA protein transferase from Escherichia coli===
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==Overview==
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Leucyl/phenylalanyl-tRNA-protein transferase (L/F-transferase) is an N-end rule pathway enzyme, which catalyzes the transfer of Leu and Phe from aminoacyl-tRNAs to exposed N-terminal Arg or Lys residues of acceptor proteins. Here, we report the 1.6 A resolution crystal structure of L/F-transferase (JW0868) from Escherichia coli, the first three-dimensional structure of an L/F-transferase. The L/F-transferase adopts a monomeric structure consisting of two domains that form a bilobate molecule. The N-terminal domain forms a small lobe with a novel fold. The large C-terminal domain has a highly conserved fold, which is observed in the GCN5-related N-acetyltransferase (GNAT) family. Most of the conserved residues of L/F-transferase reside in the central cavity, which exists at the interface between the N-terminal and C-terminal domains. A comparison of the structures of L/F-transferase and the bacterial peptidoglycan synthase FemX, indicated a structural homology in the C-terminal domain, and a similar domain interface region. Although the peptidyltransferase function is shared between the two proteins, the enzymatic mechanism would differ. The conserved residues in the central cavity of L/F-transferase suggest that this region is important for the enzyme catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 17242373 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17242373}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:16:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:46:40 2008''

Revision as of 14:46, 28 July 2008

Image:2cxa.png

Template:STRUCTURE 2cxa

Crystal structure of Leucyl/phenylalanyl-tRNA protein transferase from Escherichia coli

Template:ABSTRACT PUBMED 17242373

About this Structure

2CXA is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The crystal structure of leucyl/phenylalanyl-tRNA-protein transferase from Escherichia coli., Dong X, Kato-Murayama M, Muramatsu T, Mori H, Shirouzu M, Bessho Y, Yokoyama S, Protein Sci. 2007 Mar;16(3):528-34. Epub 2007 Jan 22. PMID:17242373

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