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2d1k

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[[Image:2d1k.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2d1k| PDB=2d1k | SCENE= }}
{{STRUCTURE_2d1k| PDB=2d1k | SCENE= }}
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'''Ternary complex of the WH2 domain of mim with actin-dnase I'''
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===Ternary complex of the WH2 domain of mim with actin-dnase I===
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==Overview==
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The adaptor protein missing-in-metastasis (MIM) contains independent F- and G-actin binding domains, consisting, respectively, of an N-terminal 250 aa IRSp53/MIM homology domain (IMD) and a C-terminal WASP-homology domain 2 (WH2). We determined the crystal structures of MIM's IMD and that of its WH2 bound to actin. The IMD forms a dimer, with each subunit folded as an antiparallel three-helix bundle. This fold is related to that of the BAR domain. Like the BAR domain, the IMD has been implicated in membrane binding. Yet, comparison of the structures reveals that the membrane binding surfaces of the two domains have opposite curvatures, which may determine the type of curvature of the interacting membrane. The WH2 of MIM is longer than the prototypical WH2, interacting with all four subdomains of actin. We characterize a similar WH2 at the C terminus of IRSp53 and propose that in these two proteins WH2 performs a scaffolding function.
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The line below this paragraph, {{ABSTRACT_PUBMED_17292833}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17292833 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17292833}}
==About this Structure==
==About this Structure==
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[[Category: Wh2]]
[[Category: Wh2]]
[[Category: Wip]]
[[Category: Wip]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:31:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:36:29 2008''

Revision as of 05:36, 28 July 2008

Image:2d1k.png

Template:STRUCTURE 2d1k

Ternary complex of the WH2 domain of mim with actin-dnase I

Template:ABSTRACT PUBMED 17292833

About this Structure

2D1K is a Protein complex structure of sequences from Bos taurus and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structural basis for the actin-binding function of missing-in-metastasis., Lee SH, Kerff F, Chereau D, Ferron F, Klug A, Dominguez R, Structure. 2007 Feb;15(2):145-55. PMID:17292833

Page seeded by OCA on Mon Jul 28 08:36:29 2008

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