2d3d

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{{STRUCTURE_2d3d| PDB=2d3d | SCENE= }}
{{STRUCTURE_2d3d| PDB=2d3d | SCENE= }}
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'''crystal structure of the RNA binding SAM domain of saccharomyces cerevisiae Vts1'''
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===crystal structure of the RNA binding SAM domain of saccharomyces cerevisiae Vts1===
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==Overview==
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The SAM domain of the Saccharomyces cerevisiae post-transcriptional regulator Vts1 has a high affinity towards RNA hairpins containing a CUGGC pentaloop. We present the 1.6 Angstroms X-ray crystal structure of the Vts1 SAM domain in its unliganded state, and the NMR solution structure of this domain in its RNA-bound state. Both structures reveal a canonical five helix SAM domain flanked by additional secondary structural elements at the N and C termini. The two structures are essentially identical, implying that no major structural rearrangements occur upon RNA binding. Amide chemical shift changes map the RNA-binding site to a shallow, basic patch at the junction of helix alpha5 and the loop connecting helices alpha1 and alpha2.
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(as it appears on PubMed at http://www.pubmed.gov), where 16375924 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16375924}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
The NMR and X-ray structures of the Saccharomyces cerevisiae Vts1 SAM domain define a surface for the recognition of RNA hairpins., Aviv T, Amborski AN, Zhao XS, Kwan JJ, Johnson PE, Sicheri F, Donaldson LW, J Mol Biol. 2006 Feb 17;356(2):274-9. Epub 2005 Dec 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16375924 16375924]
The NMR and X-ray structures of the Saccharomyces cerevisiae Vts1 SAM domain define a surface for the recognition of RNA hairpins., Aviv T, Amborski AN, Zhao XS, Kwan JJ, Johnson PE, Sicheri F, Donaldson LW, J Mol Biol. 2006 Feb 17;356(2):274-9. Epub 2005 Dec 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16375924 16375924]
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The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators., Aviv T, Lin Z, Lau S, Rendl LM, Sicheri F, Smibert CA, Nat Struct Biol. 2003 Aug;10(8):614-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12858164 12858164]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Sam domain]]
[[Category: Sam domain]]
[[Category: Sre hairpin binding]]
[[Category: Sre hairpin binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:37:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:02:56 2008''

Revision as of 16:03, 27 July 2008

Image:2d3d.png

Template:STRUCTURE 2d3d

crystal structure of the RNA binding SAM domain of saccharomyces cerevisiae Vts1

Template:ABSTRACT PUBMED 16375924

About this Structure

2D3D is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The NMR and X-ray structures of the Saccharomyces cerevisiae Vts1 SAM domain define a surface for the recognition of RNA hairpins., Aviv T, Amborski AN, Zhao XS, Kwan JJ, Johnson PE, Sicheri F, Donaldson LW, J Mol Biol. 2006 Feb 17;356(2):274-9. Epub 2005 Dec 7. PMID:16375924

The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators., Aviv T, Lin Z, Lau S, Rendl LM, Sicheri F, Smibert CA, Nat Struct Biol. 2003 Aug;10(8):614-21. PMID:12858164

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