2d3g

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[[Image:2d3g.gif|left|200px]]
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{{Seed}}
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[[Image:2d3g.png|left|200px]]
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{{STRUCTURE_2d3g| PDB=2d3g | SCENE= }}
{{STRUCTURE_2d3g| PDB=2d3g | SCENE= }}
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'''Double sided ubiquitin binding of Hrs-UIM'''
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===Double sided ubiquitin binding of Hrs-UIM===
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==Overview==
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Hrs has an essential role in sorting of monoubiquitinated receptors to multivesicular bodies for lysosomal degradation, through recognition of ubiquitinated receptors by its ubiquitin-interacting motif (UIM). Here, we present the structure of a complex of Hrs-UIM and ubiquitin at 1.7-A resolution. Hrs-UIM forms a single alpha-helix, which binds two ubiquitin molecules, one on either side. These two ubiquitin molecules are related by pseudo two-fold screw symmetry along the helical axis of the UIM, corresponding to a shift by two residues on the UIM helix. Both ubiquitin molecules interact with the UIM in the same manner, using the Ile44 surface, with equal binding affinities. Mutational experiments show that both binding sites of Hrs-UIM are required for efficient degradative protein sorting. Hrs-UIM belongs to a new subclass of double-sided UIMs, in contrast to its yeast homolog Vps27p, which has two tandem single-sided UIMs.
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The line below this paragraph, {{ABSTRACT_PUBMED_16462748}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16462748 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16462748}}
==About this Structure==
==About this Structure==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Uim and ubiquitin]]
[[Category: Uim and ubiquitin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:37:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:28:35 2008''

Revision as of 18:28, 27 July 2008

Image:2d3g.png

Template:STRUCTURE 2d3g

Double sided ubiquitin binding of Hrs-UIM

Template:ABSTRACT PUBMED 16462748

About this Structure

2D3G is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting., Hirano S, Kawasaki M, Ura H, Kato R, Raiborg C, Stenmark H, Wakatsuki S, Nat Struct Mol Biol. 2006 Mar;13(3):272-7. Epub 2006 Feb 5. PMID:16462748

Page seeded by OCA on Sun Jul 27 21:28:35 2008

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