2d3j

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[[Image:2d3j.gif|left|200px]]
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{{STRUCTURE_2d3j| PDB=2d3j | SCENE= }}
{{STRUCTURE_2d3j| PDB=2d3j | SCENE= }}
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'''NMR structure of the WIF domain from human WIF-1'''
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===NMR structure of the WIF domain from human WIF-1===
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==Overview==
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The human Wnt-binding protein Wnt-inhibitory factor-1 (WIF-1) comprises an N-terminal WIF module followed by five EGF-like repeats. Here we report the three-dimensional structure of the WIF domain of WIF-1 determined by NMR spectroscopy. The fold consists of an eight-stranded beta-sandwich reminiscent of the immunoglobulin fold. Residual detergent (Brij-35) used in the refolding protocol was found to bind tightly to the WIF domain. The binding site was identified by intermolecular nuclear Overhauser effects observed between the WIF domain and the alkyl chain of the detergent. The results point to a possible role of WIF domains as a recognition motif of Wnt and Drosophila Hedgehog proteins that are activated by palmitoylation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16476441 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16476441}}
==About this Structure==
==About this Structure==
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2D3J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D3J OCA].
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2D3J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D3J OCA].
==Reference==
==Reference==
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[[Category: Palmitoyl group]]
[[Category: Palmitoyl group]]
[[Category: Recognition domain]]
[[Category: Recognition domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:38:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:37:45 2008''

Revision as of 06:37, 28 July 2008

Image:2d3j.png

Template:STRUCTURE 2d3j

NMR structure of the WIF domain from human WIF-1

Template:ABSTRACT PUBMED 16476441

About this Structure

2D3J is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure of the WIF domain of the human Wnt-inhibitory factor-1., Liepinsh E, Banyai L, Patthy L, Otting G, J Mol Biol. 2006 Mar 31;357(3):942-50. Epub 2006 Jan 31. PMID:16476441

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