2d3w

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[[Image:2d3w.gif|left|200px]]
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{{STRUCTURE_2d3w| PDB=2d3w | SCENE= }}
{{STRUCTURE_2d3w| PDB=2d3w | SCENE= }}
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'''Crystal Structure of Escherichia coli SufC, an ATPase compenent of the SUF iron-sulfur cluster assembly machinery'''
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===Crystal Structure of Escherichia coli SufC, an ATPase compenent of the SUF iron-sulfur cluster assembly machinery===
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==Overview==
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SufC is an ATPase component of the SUF machinery, which is involved in the biosynthesis of Fe-S clusters. To gain insight into the function of this protein, we have determined the crystal structure of Escherichia coli SufC at 2.5A resolution. Despite the similarity of the overall structure with ABC-ATPases (nucleotide-binding domains of ABC transporters), some key differences were observed. Glu171, an invariant residue involved in ATP hydrolysis, is rotated away from the nucleotide-binding pocket to form a SufC-specific salt bridge with Lys152. Due to this salt bridge, D-loop that follows Glu171 is flipped out to the molecular surface, which may sterically inhibit the formation of an active dimer. Thus, the salt bridge may play a critical role in regulating ATPase activity and preventing wasteful ATP hydrolysis. Furthermore, SufC has a unique Q-loop structure on its surface, which may form a binding site for its partner proteins, SufB and/or SufD.
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(as it appears on PubMed at http://www.pubmed.gov), where 16364320 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16364320}}
==About this Structure==
==About this Structure==
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[[Category: Iron-sulfur cluster]]
[[Category: Iron-sulfur cluster]]
[[Category: Sufc]]
[[Category: Sufc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:39:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:30:15 2008''

Revision as of 10:30, 27 July 2008

Image:2d3w.png

Template:STRUCTURE 2d3w

Crystal Structure of Escherichia coli SufC, an ATPase compenent of the SUF iron-sulfur cluster assembly machinery

Template:ABSTRACT PUBMED 16364320

About this Structure

2D3W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of Escherichia coli SufC, an ABC-type ATPase component of the SUF iron-sulfur cluster assembly machinery., Kitaoka S, Wada K, Hasegawa Y, Minami Y, Fukuyama K, Takahashi Y, FEBS Lett. 2006 Jan 9;580(1):137-43. Epub 2005 Dec 6. PMID:16364320

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