2d45

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{{STRUCTURE_2d45| PDB=2d45 | SCENE= }}
{{STRUCTURE_2d45| PDB=2d45 | SCENE= }}
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'''Crystal structure of the MecI-mecA repressor-operator complex'''
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===Crystal structure of the MecI-mecA repressor-operator complex===
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==Overview==
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The dimeric repressor MecI regulates the mecA gene that encodes the penicillin-binding protein PBP-2a in methicillin-resistant Staphylococcus aureus (MRSA). MecI is similar to BlaI, the repressor for the blaZ gene of beta-lactamase. MecI and BlaI can bind to both operator DNA sequences. The crystal structure of MecI in complex with the 32 base-pair cognate DNA of mec was determined to 3.8 A resolution. MecI is a homodimer and each monomer consists of a compact N-terminal winged-helix domain, which binds to DNA, and a loosely packed C-terminal helical domain, which intertwines with its counter-monomer. The crystal contains horizontal layers of virtual DNA double helices extending in three directions, which are separated by perpendicular DNA segments. Each DNA segment is bound to two MecI dimers. Similar to the BlaI-mec complex, but unlike the MecI-bla complex, the MecI repressors bind to both sides of the mec DNA dyad that contains four conserved sequences of TACA/TGTA. The results confirm the up-and-down binding to the mec operator, which may account for cooperative effect of the repressor.
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(as it appears on PubMed at http://www.pubmed.gov), where 16582476 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16582476}}
==About this Structure==
==About this Structure==
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[[Category: Pseudo-dyad dna]]
[[Category: Pseudo-dyad dna]]
[[Category: Repressor]]
[[Category: Repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:40:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:46:20 2008''

Revision as of 10:46, 29 July 2008

Image:2d45.png

Template:STRUCTURE 2d45

Crystal structure of the MecI-mecA repressor-operator complex

Template:ABSTRACT PUBMED 16582476

About this Structure

2D45 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structure of the MecI repressor from Staphylococcus aureus in complex with the cognate DNA operator of mec., Safo MK, Ko TP, Musayev FN, Zhao Q, Wang AH, Archer GL, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt, 4):320-4. Epub 2006 Mar 25. PMID:16582476

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