2gzd
From Proteopedia
(New page: 200px<br /> <applet load="2gzd" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gzd, resolution 2.44Å" /> '''Crystal Structure o...) |
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| - | [[Image:2gzd.gif|left|200px]]<br /> | + | [[Image:2gzd.gif|left|200px]]<br /><applet load="2gzd" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2gzd, resolution 2.44Å" /> | caption="2gzd, resolution 2.44Å" /> | ||
'''Crystal Structure of Rab11 in Complex with Rab11-FIP2'''<br /> | '''Crystal Structure of Rab11 in Complex with Rab11-FIP2'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2GZD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG and GTP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 2GZD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GTP:'>GTP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZD OCA]. |
==Reference== | ==Reference== | ||
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[[Category: g protein folds]] | [[Category: g protein folds]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:29:20 2008'' |
Revision as of 15:29, 15 February 2008
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Crystal Structure of Rab11 in Complex with Rab11-FIP2
Overview
The small GTPase Rab11 regulates the recycling of endosomes to the plasma, membrane via interactions with the Rab11 family of interacting proteins, (FIPs). FIPs contain a highly conserved Rab binding domain (RBD) at their, C termini whose structure is unknown. Here, we have determined the crystal, structure of the RBD of FIP2 in complex with Rab11(GTP) by single, wavelength anomalous diffraction methods. The overall structure is a, heterotetramer with dyad symmetry, arranged as a Rab11-(FIP2)2-Rab11, complex. FIP2 forms a central alpha-helical coiled coil, with both helices, contributing to the Rab11 binding patch on equivalent and opposite sides, of the homodimer. Switch 1 of Rab11 is embedded between the two helices, while switch 2 remains flexible and is peripherally associated with the, effector. The complex reveals the structural basis for Rab11 recognition, by FIPs and suggests the molecular mechanisms underlying endocytic, recycling pathways.
About this Structure
2GZD is a Protein complex structure of sequences from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of rab11 in complex with rab11 family interacting protein 2., Jagoe WN, Lindsay AJ, Read RJ, McCoy AJ, McCaffrey MW, Khan AR, Structure. 2006 Aug;14(8):1273-83. PMID:16905101
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