2dde

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{{STRUCTURE_2dde| PDB=2dde | SCENE= }}
{{STRUCTURE_2dde| PDB=2dde | SCENE= }}
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'''Structure of cinnamycin complexed with lysophosphatidylethanolamine'''
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===Structure of cinnamycin complexed with lysophosphatidylethanolamine===
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==Overview==
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The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide.
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{{ABSTRACT_PUBMED_8882709}}
==About this Structure==
==About this Structure==
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2DDE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA].
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2DDE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA].
==Reference==
==Reference==
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[[Category: Lipid binding]]
[[Category: Lipid binding]]
[[Category: Phosphatidylethanolamine]]
[[Category: Phosphatidylethanolamine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:49:40 2008''

Revision as of 03:49, 29 July 2008

Image:2dde.png

Template:STRUCTURE 2dde

Structure of cinnamycin complexed with lysophosphatidylethanolamine

Template:ABSTRACT PUBMED 8882709

About this Structure

2DDE is a Single protein structure of sequence from Streptomyces griseoverticillatus. Full experimental information is available from OCA.

Reference

Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1., Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K, J Biochem. 1996 Feb;119(2):226-30. PMID:8882709

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