2ddu

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{{STRUCTURE_2ddu| PDB=2ddu | SCENE= }}
{{STRUCTURE_2ddu| PDB=2ddu | SCENE= }}
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'''Crystal structure of the third repeat domain of reelin'''
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===Crystal structure of the third repeat domain of reelin===
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==Overview==
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The large extracellular glycoprotein reelin directs neuronal migration during brain development and plays a fundamental role in layer formation. It is composed of eight tandem repeats of an approximately 380-residue unit, termed the reelin repeat, which has a central epidermal growth factor (EGF) module flanked by two homologous subrepeats with no obvious sequence similarity to proteins of known structure. The 2.05 A crystal structure of the mouse reelin repeat 3 reveals that the subrepeat assumes a beta-jelly-roll fold with unexpected structural similarity to carbohydrate-binding domains. Despite the interruption by the EGF module, the two subdomains make direct contact, resulting in a compact overall structure. Electron micrographs of a four-domain fragment encompassing repeats 3-6, which is capable of inducing Disabled-1 phosphorylation in neurons, show a rod-like shape. Furthermore, a three-dimensional molecular envelope of the fragment obtained by single-particle tomography can be fitted with four concatenated repeat 3 atomic structures, providing the first glimpse of the structural unit for this important signaling molecule.
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(as it appears on PubMed at http://www.pubmed.gov), where 16858396 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16858396}}
==About this Structure==
==About this Structure==
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[[Category: Yasui, N.]]
[[Category: Yasui, N.]]
[[Category: Beta-jelly-roll]]
[[Category: Beta-jelly-roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:14:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:22:45 2008''

Revision as of 14:22, 28 July 2008

Image:2ddu.png

Template:STRUCTURE 2ddu

Crystal structure of the third repeat domain of reelin

Template:ABSTRACT PUBMED 16858396

About this Structure

2DDU is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography., Nogi T, Yasui N, Hattori M, Iwasaki K, Takagi J, EMBO J. 2006 Aug 9;25(15):3675-83. Epub 2006 Jul 20. PMID:16858396

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