2dpk

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{{STRUCTURE_2dpk| PDB=2dpk | SCENE= }}
{{STRUCTURE_2dpk| PDB=2dpk | SCENE= }}
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'''The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger'''
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===The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger===
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==Overview==
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The Na+/Ca2+ exchanger is a plasma membrane protein that regulates intracellular Ca2+ levels in cardiac myocytes. Transport activity is governed by Ca2+, and the primary Ca2+ sensor (CBD1) is located in a large cytoplasmic loop connecting two transmembrane helices. The binding of Ca2+ to the CBD1 sensory domain results in conformational changes that stimulate the exchanger to extrude Ca2+. Here, we present a crystal structure of CBD1 at 2.5A resolution, which reveals a novel Ca2+ binding site consisting of four Ca2+ ions arranged in a tight planar cluster. This intricate coordination pattern for a Ca2+ binding cluster is indicative of a highly sensitive Ca2+ sensor and may represent a general platform for Ca2+ sensing.
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(as it appears on PubMed at http://www.pubmed.gov), where 16774926 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16774926}}
==About this Structure==
==About this Structure==
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[[Category: Calcium sensory domain]]
[[Category: Calcium sensory domain]]
[[Category: Cis-proline]]
[[Category: Cis-proline]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:55:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:49:23 2008''

Revision as of 17:49, 27 July 2008

Image:2dpk.png

Template:STRUCTURE 2dpk

The Crystal Structure of the Primary Ca2+ Sensor of the Na+/Ca2+ Exchanger

Template:ABSTRACT PUBMED 16774926

About this Structure

2DPK is a Single protein structure of sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.

Reference

The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif., Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J, J Biol Chem. 2006 Aug 4;281(31):21577-81. Epub 2006 Jun 14. PMID:16774926

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