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2hb1
From Proteopedia
(New page: 200px<br /> <applet load="2hb1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hb1, resolution 2.0Å" /> '''Crystal Structure of...) |
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| - | [[Image:2hb1.gif|left|200px]]<br /> | + | [[Image:2hb1.gif|left|200px]]<br /><applet load="2hb1" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2hb1" size=" | + | |
caption="2hb1, resolution 2.0Å" /> | caption="2hb1, resolution 2.0Å" /> | ||
'''Crystal Structure of PTP1B with Monocyclic Thiophene Inhibitor'''<br /> | '''Crystal Structure of PTP1B with Monocyclic Thiophene Inhibitor'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2HB1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 512 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2HB1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=512:'>512</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HB1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein-inhibitor complex]] | [[Category: protein-inhibitor complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:31:01 2008'' |
Revision as of 15:31, 15 February 2008
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Crystal Structure of PTP1B with Monocyclic Thiophene Inhibitor
Contents |
Overview
A series of monocyclic thiophenes was designed and synthesized as PTP1B, inhibitors. Guided by X-ray co-crystal structural information and, computational modeling, rational design led to key interactions with Asp48, and improved inhibitory potency against PTP1B.
Disease
Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[176885], Insulin resistance, susceptibility to OMIM:[176885]
About this Structure
2HB1 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48., Wan ZK, Lee J, Xu W, Erbe DV, Joseph-McCarthy D, Follows BC, Zhang YL, Bioorg Med Chem Lett. 2006 Sep 15;16(18):4941-5. Epub 2006 Jun 27. PMID:16806920
Page seeded by OCA on Fri Feb 15 17:31:01 2008
