2ds1

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[[Image:2ds1.jpg|left|200px]]
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{{Seed}}
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[[Image:2ds1.png|left|200px]]
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{{STRUCTURE_2ds1| PDB=2ds1 | SCENE= }}
{{STRUCTURE_2ds1| PDB=2ds1 | SCENE= }}
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'''Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor'''
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===Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor===
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==Overview==
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The design of a novel series of cyclin-dependent kinase (CDK) inhibitors containing a macrocyclic quinoxaline-2-one is reported. Structure-based drug design and optimization from the starting point of diarylurea 2, which we previously reported as a moderate CDK1,2,4,6 inhibitor [J. Biol.Chem.2001, 276, 27548], led to the discovery of potent CDK1,2,4,6 inhibitor that were suitable for iv administration for in vivo study.
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(as it appears on PubMed at http://www.pubmed.gov), where 16876403 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16876403}}
==About this Structure==
==About this Structure==
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[[Category: Inhibition]]
[[Category: Inhibition]]
[[Category: Protein kinase]]
[[Category: Protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:04:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:40:15 2008''

Revision as of 07:40, 28 July 2008

Image:2ds1.png

Template:STRUCTURE 2ds1

Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor

Template:ABSTRACT PUBMED 16876403

About this Structure

2DS1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure., Kawanishi N, Sugimoto T, Shibata J, Nakamura K, Masutani K, Ikuta M, Hirai H, Bioorg Med Chem Lett. 2006 Oct 1;16(19):5122-6. Epub 2006 Jul 28. PMID:16876403

Page seeded by OCA on Mon Jul 28 10:40:15 2008

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