2duv

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[[Image:2duv.jpg|left|200px]]
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{{Seed}}
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[[Image:2duv.png|left|200px]]
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{{STRUCTURE_2duv| PDB=2duv | SCENE= }}
{{STRUCTURE_2duv| PDB=2duv | SCENE= }}
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'''Structure of CDK2 with a 3-hydroxychromones'''
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===Structure of CDK2 with a 3-hydroxychromones===
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==Overview==
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A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.
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The line below this paragraph, {{ABSTRACT_PUBMED_17178224}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17178224 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17178224}}
==About this Structure==
==About this Structure==
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[[Category: Protein kinase]]
[[Category: Protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:25:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:17:54 2008''

Revision as of 11:18, 29 July 2008

Image:2duv.png

Template:STRUCTURE 2duv

Structure of CDK2 with a 3-hydroxychromones

Template:ABSTRACT PUBMED 17178224

About this Structure

2DUV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224

Page seeded by OCA on Tue Jul 29 14:17:54 2008

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