2hde

From Proteopedia

Revision as of 13:34, 23 January 2008

Solution Structure of Human SAP18

Overview

Signal transduction pathways are frequently found to repress transcription, of target genes in the absence of stimulation and, conversely, to, upregulate transcription in the presence of a signal. Transcription, factors are central in this dual regulatory mechanism and widely use a, generalized mechanism to repress transcription through recruitment of a, Sin3-histone deacetylase (HDAC) complex to their binding sites on DNA. The, protein SAP18 (Sin3-associated polypeptide of 18 kDa) has been shown to, play a key role in gene-specific recruitment of the HDAC complex by a, number of transcription factors including Gli, GAGA, and Bicoid. The, solution structure of SAP18 reveals a ubiquitin-like fold with several, large loop insertions relative to other family members. This fold supports, the functional role of SAP18 as a protein-protein adapter module and, provides insight for how SAP18 may bridge the Sin3-HDAC complex to, transcription factors.

About this Structure

2HDE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly., McCallum SA, Bazan JF, Merchant M, Yin J, Pan B, de Sauvage FJ, Fairbrother WJ, Biochemistry. 2006 Oct 3;45(39):11974-82. PMID:17002296

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