2e2s

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{{STRUCTURE_2e2s| PDB=2e2s | SCENE= }}
{{STRUCTURE_2e2s| PDB=2e2s | SCENE= }}
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'''Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta'''
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===Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta===
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==Overview==
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Agelenin, isolated from the Agelenidae spider Agelena opulenta, is a peptide composed of 35 amino acids. We determined the three-dimensional structure of agelenin using two-dimensional NMR spectroscopy. The structure is composed of a short antiparallel beta-sheet and four beta-turns, which are stabilized by three disulfide bonds. Agelenin has characteristic residues, Phe9, Ser28 and Arg33, which are arranged similarly to the pharmacophore of the insect channel inhibitor, omega-atracotoxin-Hv1a. These observations suggest that agelenin and omega-atracotoxin-Hv1a bind to insect calcium channels in a similar manner. We also suggest that another mode of action may operate in the channel inhibition by omega-agatoxin-IVA and omega-atracotoxin-Hv2a.
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(as it appears on PubMed at http://www.pubmed.gov), where 17644092 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17644092}}
==About this Structure==
==About this Structure==
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2E2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Allagelena_opulenta Allagelena opulenta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2S OCA].
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2E2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Allagelena_opulenta Allagelena opulenta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2S OCA].
==Reference==
==Reference==
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[[Category: Presynaptic calcium channel inhibitor]]
[[Category: Presynaptic calcium channel inhibitor]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:49:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:08:38 2008''

Revision as of 11:08, 29 July 2008

Image:2e2s.png

Template:STRUCTURE 2e2s

Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta

Template:ABSTRACT PUBMED 17644092

About this Structure

2E2S is a Single protein structure of sequence from Allagelena opulenta. Full experimental information is available from OCA.

Reference

Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors., Yamaji N, Sugase K, Nakajima T, Miki T, Wakamori M, Mori Y, Iwashita T, FEBS Lett. 2007 Aug 7;581(20):3789-94. Epub 2007 Jul 10. PMID:17644092

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