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2hko
From Proteopedia
(New page: 200px<br /> <applet load="2hko" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hko, resolution 2.80Å" /> '''Crystal structure o...) |
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caption="2hko, resolution 2.80Å" /> | caption="2hko, resolution 2.80Å" /> | ||
'''Crystal structure of LSD1'''<br /> | '''Crystal structure of LSD1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2HKO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FAD as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2HKO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FAD:'>FAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HKO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: swirm domain]] | [[Category: swirm domain]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:32:30 2008'' |
Revision as of 15:32, 15 February 2008
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Crystal structure of LSD1
Overview
Lysine-specific demethylase 1 (LSD1) was recently identified as the first, histone demethylase that specifically demethylates monomethylated and, dimethylated histone H3 at K4. It is a component of the CoREST and other, corepressor complexes and plays an important role in silencing, neuronal-specific genes in nonneuronal cells, but the molecular mechanisms, of its action remain unclear. The 2.8-A-resolution crystal structure of, the human LSD1 reveals that LSD1 defines a new subfamily of FAD-dependent, oxidases. The active center of LSD1 is characterized by a remarkable, 1,245-A3 substrate-binding cavity with a highly negative electrostatic, potential. Although the protein core of LSD1 resembles other flavoenzymes, its enzymatic activity and functions require two additional structural, modules: an N-terminal SWIRM domain important for protein stability and a, large insertion in the catalytic domain indispensable both for the, demethylase activity and the interaction with CoREST. These results, provide a framework for further probing the catalytic mechanism and the, functional roles of LSD1.
About this Structure
2HKO is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of human histone lysine-specific demethylase 1 (LSD1)., Chen Y, Yang Y, Wang F, Wan K, Yamane K, Zhang Y, Lei M, Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13956-61. Epub 2006 Sep 6. PMID:16956976
Page seeded by OCA on Fri Feb 15 17:32:30 2008
Categories: Homo sapiens | Single protein | Chen, Y. | Lei, M. | Wang, F. | Yanane, K. | Yang, Y.T. | Zhang, Y. | FAD | Amine oxidase domain | Coiled-coil | Fad binding domain | Swirm domain
