This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2e7z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2e7z.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2e7z.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2e7z| PDB=2e7z | SCENE= }}
{{STRUCTURE_2e7z| PDB=2e7z | SCENE= }}
-
'''Acetylene Hydratase from Pelobacter acetylenicus'''
+
===Acetylene Hydratase from Pelobacter acetylenicus===
-
==Overview==
+
<!--
-
The tungsten-iron-sulfur enzyme acetylene hydratase stands out from its class because it catalyzes a nonredox reaction, the hydration of acetylene to acetaldehyde. Sequence comparisons group the protein into the dimethyl sulfoxide reductase family, and it contains a bis-molybdopterin guanine dinucleotide-ligated tungsten atom and a cubane-type [4Fe:4S] cluster. The crystal structure of acetylene hydratase at 1.26 A now shows that the tungsten center binds a water molecule that is activated by an adjacent aspartate residue, enabling it to attack acetylene bound in a distinct, hydrophobic pocket. This mechanism requires a strong shift of pK(a) of the aspartate, caused by a nearby low-potential [4Fe:4S] cluster. To access this previously unrecognized W-Asp active site, the protein evolved a new substrate channel distant from where it is found in other molybdenum and tungsten enzymes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17360611}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17360611 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17360611}}
==About this Structure==
==About this Structure==
Line 20: Line 24:
==Reference==
==Reference==
Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase., Seiffert GB, Ullmann GM, Messerschmidt A, Schink B, Kroneck PM, Einsle O, Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3073-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17360611 17360611]
Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase., Seiffert GB, Ullmann GM, Messerschmidt A, Schink B, Kroneck PM, Einsle O, Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3073-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17360611 17360611]
 +
 +
Crystallization and preliminary X-ray analysis of the tungsten-dependent acetylene hydratase from Pelobacter acetylenicus., Einsle O, Niessen H, Abt DJ, Seiffert G, Schink B, Huber R, Messerschmidt A, Kroneck PM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):299-301. Epub 2005 Feb 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16511024 16511024]
[[Category: Deleted entry]]
[[Category: Deleted entry]]
[[Category: Pelobacter acetylenicus]]
[[Category: Pelobacter acetylenicus]]
Line 30: Line 36:
[[Category: Iron-sulfur-cluster]]
[[Category: Iron-sulfur-cluster]]
[[Category: Tungstoprotein]]
[[Category: Tungstoprotein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:06:23 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:34:31 2008''

Revision as of 06:34, 28 July 2008

Image:2e7z.png

Template:STRUCTURE 2e7z

Acetylene Hydratase from Pelobacter acetylenicus

Template:ABSTRACT PUBMED 17360611

About this Structure

2E7Z is a Single protein structure of sequence from Pelobacter acetylenicus. Full crystallographic information is available from OCA.

Reference

Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase., Seiffert GB, Ullmann GM, Messerschmidt A, Schink B, Kroneck PM, Einsle O, Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3073-7. PMID:17360611

Crystallization and preliminary X-ray analysis of the tungsten-dependent acetylene hydratase from Pelobacter acetylenicus., Einsle O, Niessen H, Abt DJ, Seiffert G, Schink B, Huber R, Messerschmidt A, Kroneck PM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt, 3):299-301. Epub 2005 Feb 12. PMID:16511024

Page seeded by OCA on Mon Jul 28 09:34:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2e7z"
Personal tools