2elb

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{{STRUCTURE_2elb| PDB=2elb | SCENE= }}
{{STRUCTURE_2elb| PDB=2elb | SCENE= }}
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'''Crystal Structure of the BAR-PH domain of human APPL1'''
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===Crystal Structure of the BAR-PH domain of human APPL1===
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==Overview==
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APPL1 interacts with adiponectin receptors and other important signaling molecules. It contains a BAR and a PH domain near its N terminus, and the two domains may function as a unit (BAR-PH domain). We report here the crystal structures of the BAR-PH and PTB domains of human APPL1. The structures reveal novel features for BAR domain dimerization and for the interactions between the BAR and PH domains. The BAR domain dimer of APPL1 contains two four-helical bundles, whereas other BAR domain dimers have only three helices in each bundle. The PH domain is located at the opposite ends of the BAR domain dimer. Yeast two-hybrid assays confirm the interactions between the BAR and PH domains. Lipid binding assays show that the BAR, PH, and PTB domains can bind phospholipids. The ability of APPL1 to interact with multiple signaling molecules and phospholipids supports an important role for this adaptor in cell signaling.
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(as it appears on PubMed at http://www.pubmed.gov), where 17502098 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17502098}}
==About this Structure==
==About this Structure==
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[[Category: Bar domain]]
[[Category: Bar domain]]
[[Category: Ph domain]]
[[Category: Ph domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:43:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:01:08 2008''

Revision as of 12:01, 29 July 2008

Image:2elb.png

Template:STRUCTURE 2elb

Crystal Structure of the BAR-PH domain of human APPL1

Template:ABSTRACT PUBMED 17502098

About this Structure

2ELB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of the BAR-PH and PTB domains of human APPL1., Li J, Mao X, Dong LQ, Liu F, Tong L, Structure. 2007 May;15(5):525-33. PMID:17502098

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