2i9b
From Proteopedia
(New page: 200px<br /> <applet load="2i9b" size="450" color="white" frame="true" align="right" spinBox="true" caption="2i9b, resolution 2.80Å" /> '''Crystal structure o...) |
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caption="2i9b, resolution 2.80Å" /> | caption="2i9b, resolution 2.80Å" /> | ||
'''Crystal structure of ATF-urokinase receptor complex'''<br /> | '''Crystal structure of ATF-urokinase receptor complex'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2I9B is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http:// | + | 2I9B is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I9B OCA]. |
==Reference== | ==Reference== | ||
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[[Category: urokinase receptor]] | [[Category: urokinase receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:35:21 2008'' |
Revision as of 15:35, 15 February 2008
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Crystal structure of ATF-urokinase receptor complex
Contents |
Overview
Recent studies indicate that binding of the urokinase-type plasminogen, activator (uPA) to its high-affinity receptor (uPAR) orchestrates uPAR, interactions with other cellular components that play a pivotal role in, diverse (patho-)physiological processes, including wound healing, angiogenesis, inflammation, and cancer metastasis. However, notwithstanding the wealth of biochemical data available describing the, activities of uPAR, little is known about the exact mode of uPAR/uPA, interactions or the presumed conformational changes that accompany, uPA/uPAR engagement. Here, we report the crystal structure of soluble, urokinase plasminogen activator receptor (suPAR), which contains the three, domains of the wild-type receptor but lacks the cell-surface anchoring, sequence, in complex with the amino-terminal fragment of urokinase-type, plasminogen activator (ATF), at the resolution of 2.8 A. We report the 1.9, A crystal structure of free ATF. Our results provide a structural basis, represented by conformational changes induced in uPAR, for several, published biochemical observations describing the nature of uPAR/uPA, interactions and provide insight into mechanisms that may be responsible, for the cellular responses induced by uPA binding.
Disease
Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]
About this Structure
2I9B is a Protein complex structure of sequences from Homo sapiens with as ligand. Active as U-plasminogen activator, with EC number 3.4.21.73 Full crystallographic information is available from OCA.
Reference
Structural basis of interaction between urokinase-type plasminogen activator and its receptor., Barinka C, Parry G, Callahan J, Shaw DE, Kuo A, Bdeir K, Cines DB, Mazar A, Lubkowski J, J Mol Biol. 2006 Oct 20;363(2):482-95. Epub 2006 Aug 26. PMID:16979660
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