2er9

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{{STRUCTURE_2er9| PDB=2er9 | SCENE= }}
{{STRUCTURE_2er9| PDB=2er9 | SCENE= }}
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'''X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES.'''
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===X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES.===
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==Overview==
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The conformation of a statine-containing renin inhibitor complexed with the aspartic proteinase from the fungus Endothia parasitica (EC 3.4.23.6) has been determined by X-ray diffraction at 2.2-A resolution (R = 0.17). We describe the structure of the complex at high resolution and compare this with a 3.0-A resolution analysis of a bound inhibitor, L-364,099, containing a cyclohexylalanine analogue of statine. The inhibitors bind in extended conformations in the long active-site cleft, and the hydroxyl of the transition-state analogue, statine, interacts strongly with the catalytic aspartates via hydrogen bonds to the essential carboxyl groups. This work provides a detailed structural analysis of the role of statine in peptide inhibitors. It shows conclusively that statine should be considered a dipeptide analogue (occupying P1 to P1') despite lacking the equivalent of a P1' side chain, although other inhibitor residues (especially P2) may compensate by interacting at the unoccupied S1' specificity subsite.
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The line below this paragraph, {{ABSTRACT_PUBMED_2690945}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 2690945 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2690945}}
==About this Structure==
==About this Structure==
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[[Category: Cooper, J B.]]
[[Category: Cooper, J B.]]
[[Category: Foundling, S I.]]
[[Category: Foundling, S I.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:01:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:33:18 2008''

Revision as of 06:33, 29 July 2008

Image:2er9.png

Template:STRUCTURE 2er9

X-RAY STUDIES OF ASPARTIC PROTEINASE-STATINE INHIBITOR COMPLEXES.

Template:ABSTRACT PUBMED 2690945

About this Structure

2ER9 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

X-ray studies of aspartic proteinase-statine inhibitor complexes., Cooper JB, Foundling SI, Blundell TL, Boger J, Jupp RA, Kay J, Biochemistry. 1989 Oct 17;28(21):8596-603. PMID:2690945

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