2etw

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[[Image:2etw.gif|left|200px]]
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{{STRUCTURE_2etw| PDB=2etw | SCENE= }}
{{STRUCTURE_2etw| PDB=2etw | SCENE= }}
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'''Principles of protein-DNA recognition revealed in the structural analysis of Ndt80-MSE DNA complexes'''
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===Principles of protein-DNA recognition revealed in the structural analysis of Ndt80-MSE DNA complexes===
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==Overview==
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The Saccharomyces cerevisiae transcription factor Ndt80 selectively binds a DNA consensus sequence (the middle sporulation element [MSE]) to activate gene expression after the successful completion of meiotic recombination. Here we report the X-ray crystal structures of Ndt80 bound to ten distinct MSE variants. Comparison of these structures with the structure of Ndt80 bound to a consensus MSE reveals structural principles that determine the DNA binding specificity of this transcription factor. The 5' GC-rich end of the MSE contains distinct 5'-YpG-3' steps that are recognized by arginine side chains through a combination of hydrogen bonding and cation-pi interactions. The 3' AT-rich region is recognized via minor groove contacts that sterically exclude the N2 atom of GC base pairs. The conformation of the AT-rich region is fixed by interactions with the protein that favor recognition of poly(A)-poly(T) versus mixed AT sequences through an avoidance of major groove steric clashes at 5'-ApT-3' steps.
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(as it appears on PubMed at http://www.pubmed.gov), where 16531239 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16531239}}
==About this Structure==
==About this Structure==
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[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
[[Category: Ig-fold]]
[[Category: Ig-fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:06:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:33:48 2008''

Revision as of 21:33, 27 July 2008

Image:2etw.png

Template:STRUCTURE 2etw

Principles of protein-DNA recognition revealed in the structural analysis of Ndt80-MSE DNA complexes

Template:ABSTRACT PUBMED 16531239

About this Structure

2ETW is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Principles of protein-DNA recognition revealed in the structural analysis of Ndt80-MSE DNA complexes., Lamoureux JS, Glover JN, Structure. 2006 Mar;14(3):555-65. PMID:16531239

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