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2eu3

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[[Image:2eu3.gif|left|200px]]
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{{STRUCTURE_2eu3| PDB=2eu3 | SCENE= }}
{{STRUCTURE_2eu3| PDB=2eu3 | SCENE= }}
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'''Human Carbonic anhydrase II in complex with novel inhibitors'''
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===Human Carbonic anhydrase II in complex with novel inhibitors===
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==Overview==
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Human carbonic anhydrases (CAs) are well studied targets for the development of inhibitors for pharmaceutical applications. The crystal structure of human CA II has been determined in complex with two CA inhibitors (CAIs) containing conventional sulfonamide and thiadiazole moieties separated by a -CF2- or -CHNH2- spacer group. The structures presented here reveal that these spacer groups allow novel binding modes for the thiadiazole moiety compared with conventional CAIs.
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(as it appears on PubMed at http://www.pubmed.gov), where 16820676 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16820676}}
==Disease==
==Disease==
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[[Category: Silverman, D N.]]
[[Category: Silverman, D N.]]
[[Category: Carbonic anhydrase ii proton transfer inhibitor]]
[[Category: Carbonic anhydrase ii proton transfer inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:06:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:13:55 2008''

Revision as of 23:13, 28 July 2008

Image:2eu3.png

Template:STRUCTURE 2eu3

Contents

Human Carbonic anhydrase II in complex with novel inhibitors

Template:ABSTRACT PUBMED 16820676

Disease

Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]

About this Structure

2EU3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes., Fisher SZ, Govindasamy L, Boyle N, Agbandje-McKenna M, Silverman DN, Blackburn GM, McKenna R, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):618-22. Epub 2006 Jun 10. PMID:16820676

Page seeded by OCA on Tue Jul 29 02:13:55 2008

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