2evl

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{{STRUCTURE_2evl| PDB=2evl | SCENE= }}
{{STRUCTURE_2evl| PDB=2evl | SCENE= }}
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'''Crystal structure of human Glycolipid Transfer Protein complexed with 18:2 Galactosylceramide'''
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===Crystal structure of human Glycolipid Transfer Protein complexed with 18:2 Galactosylceramide===
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==Overview==
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Glycosphingolipids (GSLs) play major roles in cellular growth and development. Mammalian glycolipid transfer proteins (GLTPs) are potential regulators of cell processes mediated by GSLs and display a unique architecture among lipid binding/transfer proteins. The GLTP fold represents a novel membrane targeting/interaction domain among peripheral proteins. Here we report crystal structures of human GLTP bound to GSLs of diverse acyl chain length, unsaturation, and sugar composition. Structural comparisons show a highly conserved anchoring of galactosyl- and lactosyl-amide headgroups by the GLTP recognition center. By contrast, acyl chain chemical structure and occupancy of the hydrophobic tunnel dictate partitioning between sphingosine-in and newly-observed sphingosine-out ligand-binding modes. The structural insights, combined with computed interaction propensity distributions, suggest a concerted sequence of events mediated by GLTP conformational changes during GSL transfer to and/or from membranes, as well as during GSL presentation and/or transfer to other proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17105344 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17105344}}
==About this Structure==
==About this Structure==
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[[Category: Patel, D J.]]
[[Category: Patel, D J.]]
[[Category: Protein-glycolipid complex]]
[[Category: Protein-glycolipid complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:09:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:21:43 2008''

Revision as of 13:21, 27 July 2008

Image:2evl.png

Template:STRUCTURE 2evl

Crystal structure of human Glycolipid Transfer Protein complexed with 18:2 Galactosylceramide

Template:ABSTRACT PUBMED 17105344

About this Structure

2EVL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure., Malinina L, Malakhova ML, Kanack AT, Lu M, Abagyan R, Brown RE, Patel DJ, PLoS Biol. 2006 Nov;4(11):e362. PMID:17105344

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