2evs

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{{STRUCTURE_2evs| PDB=2evs | SCENE= }}
{{STRUCTURE_2evs| PDB=2evs | SCENE= }}
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'''Crystal structure of human Glycolipid Transfer Protein complexed with n-hexyl-beta-D-glucoside'''
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===Crystal structure of human Glycolipid Transfer Protein complexed with n-hexyl-beta-D-glucoside===
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==Overview==
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Glycosphingolipids (GSLs) play major roles in cellular growth and development. Mammalian glycolipid transfer proteins (GLTPs) are potential regulators of cell processes mediated by GSLs and display a unique architecture among lipid binding/transfer proteins. The GLTP fold represents a novel membrane targeting/interaction domain among peripheral proteins. Here we report crystal structures of human GLTP bound to GSLs of diverse acyl chain length, unsaturation, and sugar composition. Structural comparisons show a highly conserved anchoring of galactosyl- and lactosyl-amide headgroups by the GLTP recognition center. By contrast, acyl chain chemical structure and occupancy of the hydrophobic tunnel dictate partitioning between sphingosine-in and newly-observed sphingosine-out ligand-binding modes. The structural insights, combined with computed interaction propensity distributions, suggest a concerted sequence of events mediated by GLTP conformational changes during GSL transfer to and/or from membranes, as well as during GSL presentation and/or transfer to other proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17105344 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17105344}}
==About this Structure==
==About this Structure==
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[[Category: Patel, D J.]]
[[Category: Patel, D J.]]
[[Category: Protein complex with detergent]]
[[Category: Protein complex with detergent]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:10:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:27:39 2008''

Revision as of 06:27, 29 July 2008

Image:2evs.png

Template:STRUCTURE 2evs

Crystal structure of human Glycolipid Transfer Protein complexed with n-hexyl-beta-D-glucoside

Template:ABSTRACT PUBMED 17105344

About this Structure

2EVS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure., Malinina L, Malakhova ML, Kanack AT, Lu M, Abagyan R, Brown RE, Patel DJ, PLoS Biol. 2006 Nov;4(11):e362. PMID:17105344

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