2ex5

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{{STRUCTURE_2ex5| PDB=2ex5 | SCENE= }}
{{STRUCTURE_2ex5| PDB=2ex5 | SCENE= }}
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'''Group I Intron-encoded Homing Endonuclease I-CeuI Complexed With DNA'''
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===Group I Intron-encoded Homing Endonuclease I-CeuI Complexed With DNA===
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==Overview==
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Homing endonucleases are highly specific catalysts of DNA strand breaks, leading to the transfer of mobile intervening sequences containing the endonuclease ORF. We have determined the structure and DNA recognition behavior of I-CeuI, a homodimeric LAGLIDADG endonuclease from Chlamydomonas eugametos. This symmetric endonuclease displays unique structural elaborations on its core enzyme fold, and it preferentially cleaves a highly asymmetric target site. This latter property represents an early step, prior to gene fusion, in the generation of asymmetric DNA binding platforms from homodimeric ancestors. The divergence of the sequence, structure, and target recognition behavior of homing endonucleases, as illustrated by this study, leads to the invasion of novel genomic sites by mobile introns during evolution.
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(as it appears on PubMed at http://www.pubmed.gov), where 16698548 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16698548}}
==About this Structure==
==About this Structure==
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[[Category: Laglidadg]]
[[Category: Laglidadg]]
[[Category: Protein/dna complex]]
[[Category: Protein/dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:12:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 6 12:06:08 2008''

Revision as of 09:06, 6 July 2008

Image:2ex5.png

Template:STRUCTURE 2ex5

Group I Intron-encoded Homing Endonuclease I-CeuI Complexed With DNA

Template:ABSTRACT PUBMED 16698548

About this Structure

2EX5 is a Single protein structure of sequence from Chlamydomonas eugametos. Full crystallographic information is available from OCA.

Reference

The structure of I-CeuI homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold., Spiegel PC, Chevalier B, Sussman D, Turmel M, Lemieux C, Stoddard BL, Structure. 2006 May;14(5):869-80. PMID:16698548

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