2ilt

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(New page: 200px<br /> <applet load="2ilt" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ilt, resolution 2.300&Aring;" /> '''Human 11-beta-Hydr...)
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'''Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor'''<br />
'''Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor'''<br />
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==About this Structure==
==About this Structure==
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2ILT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NI, NAP and NN1 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ILT OCA].
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2ILT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NI:'>NI</scene>, <scene name='pdbligand=NAP:'>NAP</scene> and <scene name='pdbligand=NN1:'>NN1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ILT OCA].
==Reference==
==Reference==
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[[Category: nadp]]
[[Category: nadp]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:45:52 2007''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:36:30 2008''

Revision as of 15:36, 15 February 2008

Image:2ilt.jpg

2ilt, resolution 2.300Å

Drag the structure with the mouse to rotate

Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor

Contents

Overview

Potent and selective adamantane sulfone and sulfonamide inhibitors of, 11-beta-HSD-1 have been discovered. Selected compounds from these series, have robust pharmacokinetic profiles and strongly inhibit liver, fat, and, brain HSD1 for extended periods after oral dosing.

Disease

Known diseases associated with this structure: Cortisone reductase deficiency OMIM:[600713]

About this Structure

2ILT is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as 11-beta-hydroxysteroid dehydrogenase, with EC number 1.1.1.146 Full crystallographic information is available from OCA.

Reference

Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors., Sorensen B, Winn M, Rohde J, Shuai Q, Wang J, Fung S, Monzon K, Chiou W, Stolarik D, Imade H, Pan L, Deng X, Chovan L, Longenecker K, Judge R, Qin W, Brune M, Camp H, Frevert EU, Jacobson P, Link JT, Bioorg Med Chem Lett. 2007 Jan 15;17(2):527-32. Epub 2006 Oct 7. PMID:17070044

Page seeded by OCA on Fri Feb 15 17:36:30 2008

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