2f2h

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[[Image:2f2h.gif|left|200px]]
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{{STRUCTURE_2f2h| PDB=2f2h | SCENE= }}
{{STRUCTURE_2f2h| PDB=2f2h | SCENE= }}
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'''Structure of the YicI thiosugar Michaelis complex'''
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===Structure of the YicI thiosugar Michaelis complex===
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==Overview==
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For the first time, the thioglycoligase strategy has been successfully applied to alpha-glycosidases. The alpha-thioglycoligases derived from the family 31 glycosidases, alpha-xylosidase from E. coli (YicI) and alpha-glucosidase from Sulfolobus solfataricus, catalyze thioglycoligase reactions using alpha-glycosyl fluorides and deoxythioglycosides as donors and acceptors, respectively, in yields up to 86%. In addition, we describe the Michaelis complex of YicI using one of the thioglycosides as a nonhydrolyzable substrate analogue and discuss the structural insights this yields into the specificity and mechanism of family 31 alpha-glycosidases and the molecular basis of an associated genetic disease.
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(as it appears on PubMed at http://www.pubmed.gov), where 16478160 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16478160}}
==About this Structure==
==About this Structure==
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[[Category: Withers, S G.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:23:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:19:06 2008''

Revision as of 06:19, 28 July 2008

Image:2f2h.png

Template:STRUCTURE 2f2h

Structure of the YicI thiosugar Michaelis complex

Template:ABSTRACT PUBMED 16478160

About this Structure

2F2H is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Expanding the thioglycoligase strategy to the synthesis of alpha-linked thioglycosides allows structural investigation of the parent enzyme/substrate complex., Kim YW, Lovering AL, Chen H, Kantner T, McIntosh LP, Strynadka NC, Withers SG, J Am Chem Soc. 2006 Feb 22;128(7):2202-3. PMID:16478160

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