2f2i

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[[Image:2f2i.gif|left|200px]]
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{{Seed}}
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[[Image:2f2i.png|left|200px]]
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{{STRUCTURE_2f2i| PDB=2f2i | SCENE= }}
{{STRUCTURE_2f2i| PDB=2f2i | SCENE= }}
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'''Solution structure of [P20D,V21K]-kalata B1'''
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===Solution structure of [P20D,V21K]-kalata B1===
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==Overview==
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The cyclotide family of plant proteins is of interest because of their unique topology, which combines a head-to-tail cyclic backbone with an embedded cystine knot, and because their remarkable chemical and biological properties make them ideal candidates as grafting templates for biologically active peptide epitopes. The present study describes the first steps towards exploiting the cyclotide framework by synthesizing and structurally characterizing two grafted analogues of the cyclotide kalata B1. The modified peptides have polar or charged residues substituted for residues that form part of a surface-exposed hydrophobic patch that plays a significant role in the folding and biological activity of kalata B1. Both analogues retain the native cyclotide fold, but lack the undesired haemolytic activity of their parent molecule, kalata B1. This finding confirms the tolerance of the cyclotide framework to residue substitutions and opens up possibilities for the substitution of biologically active peptide epitopes into the framework.
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The line below this paragraph, {{ABSTRACT_PUBMED_16300479}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16300479 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16300479}}
==About this Structure==
==About this Structure==
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2F2I is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2I OCA].
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2F2I is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2I OCA].
==Reference==
==Reference==
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[[Category: Circular backbone]]
[[Category: Circular backbone]]
[[Category: Cystine knot]]
[[Category: Cystine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:23:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:23:42 2008''

Revision as of 03:23, 29 July 2008

Image:2f2i.png

Template:STRUCTURE 2f2i

Solution structure of [P20D,V21K]-kalata B1

Template:ABSTRACT PUBMED 16300479

About this Structure

2F2I is a Single protein structure. Full experimental information is available from OCA.

Reference

Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design., Clark RJ, Daly NL, Craik DJ, Biochem J. 2006 Feb 15;394(Pt 1):85-93. PMID:16300479

Page seeded by OCA on Tue Jul 29 06:23:42 2008

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